Seroatlas · Human Serome Atlas

CCL14

C-C motif chemokine 14

Also known as: CCL14_HUMAN, CKb1, HCC-1, HCC-3, MCIF, NCC-2, SCYA14, SCYL2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16627
Gene: CCL14
Ensembl: ENSG00000276409
Chromosome: 17
Canonical length: 93 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249. [provided by RefSeq, Dec 2009]

Canonical amino-acid sequenceUniProt

93 residues, UniProt reviewed canonical sequence.

>Q16627|CCL14
     1  MKISVAAIPF FLLITIALGT KTESSSRGPY HPSECCFTYT TYKIPRQRIM DYYETNSQCS
    61  KPGIVFITKR GHSVCTNPSD KWVQDYIKDM KEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 696 nTPM

Expression across tissuesHPA

Tissue

spleen: 696 nTPM
adipose tissue: 419 nTPM
breast: 410 nTPM
fallopian tube: 250 nTPM
endometrium: 224 nTPM
blood vessel: 221 nTPM

Single-cell type

vascular endothelial cells: 0.8 nCPM
ependymal cells: 0.3 nCPM
late spermatids: 0.3 nCPM
enterocytes: 0.2 nCPM
colonocytes: 0.1 nCPM
goblet cells: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 5.3 nTPM
pons: 0.9 nTPM
cerebral cortex: 0.7 nTPM
medulla oblongata: 0.6 nTPM
amygdala: 0.4 nTPM
spinal cord: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0
gnomAD missense Z: 0.04
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL14 as an antibody target. Whether an autoantibody or antibody against CCL14 could matter depends on whether native CCL14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL14 is annotated as secreted, so native CCL14 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCL14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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