Seroatlas · Human Serome Atlas

CCL13

C-C motif chemokine 13

Also known as: CCL13_HUMAN, CKb10, MCP-4, MGC17134, NCC-1, SCYA13, SCYL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99616
Gene: CCL13
Ensembl: ENSG00000181374
Chromosome: 17
Canonical length: 98 aa
Protein class: Cancer-related genes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

98 residues, UniProt reviewed canonical sequence.

>Q99616|CCL13
     1  MKVSAVLLCL LLMTAAFNPQ GLAQPDALNV PSTCCFTFSS KKISLQRLKS YVITTSRCPQ
    61  KAVIFRTKLG KEICADPKEK WVQNYMKHLG RKAHTLKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

colon: 31 nTPM
urinary bladder: 28 nTPM
small intestine: 26 nTPM
rectum: 24 nTPM
adipose tissue: 22 nTPM
lung: 21 nTPM

Single-cell type

hofbauer cells: 109 nCPM
macrophages: 41 nCPM
cdc: 21 nCPM
pericytes: 8.2 nCPM
fibroblasts: 4.4 nCPM
decidual stromal cells: 3.9 nCPM

Immune cell

classical monocyte: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.9 nTPM
choroid plexus: 0.1 nTPM
hippocampal formation: 0.1 nTPM
hypothalamus: 0.1 nTPM
thalamus: 0.1 nTPM
white matter: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0.04
gnomAD missense Z: 0.1
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL13 as an antibody target. Whether an autoantibody or antibody against CCL13 could matter depends on whether native CCL13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL13 is annotated as secreted, so native CCL13 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCL13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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