Seroatlas · Human Serome Atlas

CCL11

Eotaxin

Also known as: CCL11_HUMAN, eotaxin, MGC22554, SCYA11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51671
Gene: CCL11
Ensembl: ENSG00000172156
Chromosome: 17
Canonical length: 97 aa
Protein class: Cancer-related genes, Human disease related genes, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

97 residues, UniProt reviewed canonical sequence.

>P51671|CCL11
     1  MKVSAALLWL LLIAAAFSPQ GLAGPASVPT TCCFNLANRK IPLQRLESYR RITSGKCPQK
    61  AVIFKTKLAK DICADPKKKW VQDSMKYLDQ KSPTPKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

colon: 43 nTPM
urinary bladder: 38 nTPM
small intestine: 34 nTPM
stomach: 33 nTPM
duodenum: 31 nTPM
appendix: 30 nTPM

Single-cell type

fibroblasts: 43 nCPM
foveolar cells: 3.1 nCPM
schwann cells: 3 nCPM
gastric chief cells: 2.2 nCPM
parietal cells: 1.8 nCPM
pericytes: 1.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0.01
gnomAD missense Z: -0.41
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL11 as an antibody target. Whether an autoantibody or antibody against CCL11 could matter depends on whether native CCL11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL11 is annotated as secreted, so native CCL11 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCL11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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