Seroatlas · Human Serome Atlas

CCL1

C-C motif chemokine 1

Also known as: CCL1_HUMAN, I-309, P500, SCYA1, SISe, TCA3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P22362
Gene: CCL1
Ensembl: ENSG00000108702
Chromosome: 17
Canonical length: 96 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

96 residues, UniProt reviewed canonical sequence.

>P22362|CCL1
     1  MQIITTALVC LLLAGMWPED VDSKSMQVPF SRCCFSFAEQ EIPLRAILCY RNTSSICSNE
    61  GLIFKLKRGK EACALDTVGW VQRHRKMLRH CPSKRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 2.1 nTPM

Expression across tissuesHPA

Tissue

rectum: 2.1 nTPM
thymus: 1.1 nTPM
testis: 0.3 nTPM
basal ganglia: 0.2 nTPM
cerebral cortex: 0.2 nTPM
colon: 0.2 nTPM

Single-cell type

early spermatids: 3.2 nCPM
t-cells: 2.6 nCPM
late spermatids: 2.5 nCPM
thymocytes: 1.7 nCPM
basal keratinocytes: 0.3 nCPM
plasma cells: 0.3 nCPM

Immune cell

classical monocyte: 0.3 nTPM
intermediate monocyte: 0.2 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.1 nTPM
white matter: 0.3 nTPM
hippocampal formation: 0.2 nTPM
hypothalamus: 0.2 nTPM
midbrain: 0.2 nTPM
amygdala: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.82
gnomAD pLI: 0.01
gnomAD missense Z: 0.25
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL1 as an antibody target. Whether an autoantibody or antibody against CCL1 could matter depends on whether native CCL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL1 is annotated as secreted, so native CCL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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