CCK
Cholecystokinin
Also known as: CCKN_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P06307
- Gene
- CCK
- Ensembl
- ENSG00000187094
- Chromosome
- 3
- Canonical length
- 115 aa
- Protein class
- Plasma proteins, Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Canonical amino-acid sequenceUniProt
115 residues, UniProt reviewed canonical sequence.
>P06307|CCK
1 MNSGVCLCVL MAVLAAGALT QPVPPADPAG SGLQRAEEAP RRQLRVSQRT DGESRAHLGA
61 LLARYIQQAR KAPSGRMSIV KNLQNLDPSH RISDRDYMGW MDFGRRSAEE YEYPSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CCK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.6
- Highest tissue expression
- 432 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 432 nTPM
- amygdala: 242 nTPM
- hippocampal formation: 145 nTPM
- duodenum: 109 nTPM
- basal ganglia: 44 nTPM
- hypothalamus: 41 nTPM
Single-cell type
- brain inhibitory neurons: 202 nCPM
- neuroendocrine cells: 172 nCPM
- brain excitatory neurons: 94 nCPM
- corticotrophs: 90 nCPM
- other brain neurons: 43 nCPM
- gastric progenitor cells: 32 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 246 nTPM
- basal ganglia: 129 nTPM
- white matter: 125 nTPM
- hippocampal formation: 122 nTPM
- amygdala: 103 nTPM
- thalamus: 81 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.9
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.65
- DepMap mean gene effect
- 0
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- axonogenesis
- cholecystokinin signaling pathway
- digestion
- eating behavior
- neuron migration
- signal transduction
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CCK as an antibody target. Whether an autoantibody or antibody against CCK could matter depends on whether native CCK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CCK is annotated as secreted, so native CCK circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label CCK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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