Seroatlas · Human Serome Atlas

CCER2

Coiled-coil domain-containing glutamate-rich protein 2

Also known as: CCER2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
I3L3R5
Gene
CCER2
Ensembl
ENSG00000262484
Chromosome
19
Canonical length
266 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted - unknown location

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

266 residues, UniProt reviewed canonical sequence.

>I3L3R5|CCER2
     1  MPPRGPASEL LLLRLLLLGA ATAAPLAPRP SKEELTRCLA EVVTEVLTVG QVQRGPCTAL
    61  LHKELCGTEP HGCASTEEKG LLLGDFKKQE AGKMRSSQEV RDEEEEEVAE RTHKSEVQEQ
   121  AIRMQGHRQL HQEEDEEEEK EERKRGPMET FEDLWQRHLE NGGDLQKRVA EKASDKETAQ
   181  FQAEEKGVRV LGGDRSLWQG AERGGGERRE DLPHHHHHHH QPEAEPRQEK EEASEREEKE
   241  VEQLEHLRDE LKKVTETLGE QLRREG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCER2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
4.7 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 4.7 nTPM
  • testis: 4.7 nTPM
  • basal ganglia: 4.6 nTPM
  • spinal cord: 4.1 nTPM
  • skin: 4 nTPM
  • cerebral cortex: 3.6 nTPM

Single-cell type

  • basal keratinocytes: 39 nCPM
  • late spermatids: 5.5 nCPM
  • oligodendrocyte progenitor cells: 4.8 nCPM
  • brain inhibitory neurons: 3.1 nCPM
  • astrocytes: 2.8 nCPM
  • oligodendrocytes: 2.7 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 5.1 nTPM
  • cerebral cortex: 3.7 nTPM
  • basal ganglia: 3 nTPM
  • pons: 2.8 nTPM
  • white matter: 2.8 nTPM
  • cerebellum: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.14
gnomAD pLI
0
gnomAD missense Z
0.26
DepMap mean gene effect
0.06
DepMap dependency class
selective

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCER2 as an antibody target. Whether an autoantibody or antibody against CCER2 could matter depends on whether native CCER2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCER2 is annotated as secreted, so native CCER2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCER2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCER2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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