Seroatlas · Human Serome Atlas

CCER1

Coiled-coil domain-containing glutamate-rich protein 1

Also known as: C12orf12, CCER1_HUMAN, MGC26598

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TC90
Gene: CCER1
Ensembl: ENSG00000197651
Chromosome: 12
Canonical length: 406 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CCER1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

406 residues, UniProt reviewed canonical sequence.

>Q8TC90|CCER1
     1  MTQTLDTRED PLNLGGGGGG GCGCGWAHSA SLSSWSSCHR RRPGAPAYNR PHRYSPKTEY
    61  GPPRKQPKQQ HGPGFWFQPP VCSNWGCWGG PWRPPPPGFW KFPCPVQVFR VYGLHPLCFC
   121  CCSCWSGSWN PGWVKPPGRK KRWGRRGRGL RHHPRHSYPR SPPADVSTLP RPVKLYEWRE
   181  PGMRAPPNTT QFIMNQIYED MRQQEKVERQ QEALRAQKAT VSGEASPARS SGNDAPPGGS
   241  KETWGLQETL YGFVQNPSLA FSPNPEENQS LAPLLVEEEE EKKNDDEEEY DQEVCDAKEA
   301  SEEEEEVEDE EEEVEDEEEE EVEEAEYVEE GEEELEEEEL EEEEEVLEEN EQRGEEFHLP
   361  LEMPLSIFVE AEEKRENFIS CTFLNPEQII PKVPQESLFM AQDFNC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCER1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

testis: 36 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early spermatids: 455 nCPM
late primary spermatocytes: 396 nCPM
late spermatids: 131 nCPM
early primary spermatocytes: 2.8 nCPM
leydig cells: 1.6 nCPM
sertoli cells: 1.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 0.64
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing glutamate-rich protein family 1
Coiled-coil domain-containing protein
Coiled-coil domain-containing glutamate-rich protein family 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCER1 as an antibody target. Whether an autoantibody or antibody against CCER1 could matter depends on whether native CCER1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCER1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCER1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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