Seroatlas · Human Serome Atlas

CCDC9B

Coiled-coil domain-containing protein 9B

Also known as: C15orf52, CCD9B_HUMAN, FLJ43339

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZUT6
Gene: CCDC9B
Ensembl: ENSG00000188549
Chromosome: 15
Canonical length: 534 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

534 residues, UniProt reviewed canonical sequence.

>Q6ZUT6|CCDC9B
     1  MISCAEQRSR QGEAGRGPAP VAPAFLPLWL PRGCSGILSV PAVAMHSAGT PRAESPMSRQ
    61  EKDAELDRRI VALRKKNQAL LRRYQEIQED RRQAEQGGMA VTTPALLQPD GLTVTISQVP
   121  GEKRVVSRNW ARGTCGPRVT NEMLEDEDAE DHGGTFCLGE LVELAVTMEN KAEGKRIVSE
   181  KPTRARNQGI EGSPGGRVTR SPPTQVAISS DSARKGSWEP WSRPVGEPPE AGWDYAQWKQ
   241  EREQIDLARL ARHRDAQGDW RRPWDLDKAK STLQDCSQLR GEGPARAGSR RGPRSHQKLQ
   301  PPPLLPDGKG RGGQASRPSV APATGSKARG KERLTGRARR WDMKEDKEEL EGQEGSQSTR
   361  ETPSEEEQAQ KQSGMEQGRL GSAPAASPAL ASPEGPKGES VASTASSVPC SPQEPDLAPL
   421  DLSLGGAGIP GPRESGCVLG LRPGAQESPV SWPEGSKQQP LGWSNHQAEL EVQTCPEPQR
   481  GAGLPEPGED RSGKSGAQQG LAPRSRPTRG GSQRSRGTAG VRRRTGRPGP AGRC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC9B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 57 nTPM
tongue: 34 nTPM
colon: 28 nTPM
heart muscle: 26 nTPM
thyroid gland: 19 nTPM
esophagus: 17 nTPM

Single-cell type

esophageal apical cells: 52 nCPM
myonuclei: 45 nCPM
cardiomyocytes: 43 nCPM
megakaryocytes: 37 nCPM
alveolar cells type 1: 24 nCPM
cholangiocytes: 21 nCPM

Immune cell

eosinophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 20 nTPM
thalamus: 14 nTPM
medulla oblongata: 13 nTPM
basal ganglia: 12 nTPM
hypothalamus: 12 nTPM
midbrain: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
DepMap mean gene effect: -0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC9B as an antibody target. Whether an autoantibody or antibody against CCDC9B could matter depends on whether native CCDC9B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC9B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC9B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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