Seroatlas · Human Serome Atlas

CCDC92B

Coiled-coil domain-containing 92B

Also known as: CC92B_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A8I5KY20
Gene
CCDC92B
Canonical length
255 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CCDC92B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

255 residues, UniProt reviewed canonical sequence.

>A0A8I5KY20|CCDC92B
     1  MDTVSLEHQI QSVQRHISFL KKEQMALLRD LHLEILRLQK RCSELTHDLE MREAQSHQQE
    61  AASRELESKC RALESQLEAR AAANAELRRE VAQREALVSA LRCSLRTEER RFLEELRRRS
   121  HRATVLGTEL QKHTEAAAYL SCQLHAARQR LQAPRPGPGA TAEPRPRRRA LRARRPPAAH
   181  EAAAKGPGRD WAAWDRGAGA LDDADPMPDP ALFLYARRPL RPSARSPRQP PPQEPPDRAG
   241  PQPAPSQPSA PGDPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC92B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
4.6 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 4.6 nTPM
  • retina: 3.9 nTPM
  • adrenal gland: 0.8 nTPM
  • testis: 0.7 nTPM
  • skin: 0.6 nTPM
  • duodenum: 0.4 nTPM

Single-cell type

  • undifferentiated spermatogonia: 26 nCPM
  • retinal horizontal cells: 24 nCPM
  • rod photoreceptor cells: 22 nCPM
  • retinal bipolar cells: 22 nCPM
  • retinal amacrine cells: 20 nCPM
  • differentiating spermatogonia: 18 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 22 nTPM
  • cerebral cortex: 22 nTPM
  • hypothalamus: 17 nTPM
  • hippocampal formation: 16 nTPM
  • pons: 16 nTPM
  • amygdala: 15 nTPM

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC92B as an antibody target. Whether an autoantibody or antibody against CCDC92B could matter depends on whether native CCDC92B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC92B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC92B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC92B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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