Seroatlas · Human Serome Atlas

CCDC9

Coiled-coil domain-containing protein 9

Also known as: CCDC9_HUMAN, DKFZP586M1019

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3X0
Gene: CCDC9
Ensembl: ENSG00000105321
Chromosome: 19
Canonical length: 531 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Part of exon-exon junction complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

531 residues, UniProt reviewed canonical sequence.

>Q9Y3X0|CCDC9
     1  MAATLDLKSK EEKDAELDKR IEALRRKNEA LIRRYQEIEE DRKKAELEGV AVTAPRKGRS
    61  VEKENVAVES EKNLGPSRRS PGTPRPPGAS KGGRTPPQQG GRAGMGRASR SWEGSPGEQP
   121  RGGGAGGRGR RGRGRGSPHL SGAGDTSISD RKSKEWEERR RQNIEKMNEE MEKIAEYERN
   181  QREGVLEPNP VRNFLDDPRR RSGPLEESER DRREESRRHG RNWGGPDFER VRCGLEHERQ
   241  GRRAGLGSAG DMTLSMTGRE RSEYLRWKQE REKIDQERLQ RHRKPTGQWR REWDAEKTDG
   301  MFKDGPVPAH EPSHRYDDQA WARPPKPPTF GEFLSQHKAE ASSRRRRKSS RPQAKAAPRA
   361  YSDHDDRWET KEGAASPAPE TPQPTSPETS PKETPMQPPE IPAPAHRPPE DEGEENEGEE
   421  DEEWEDISED EEEEEIEVEE GDEEEPAQDH QAPEAAPTGI PCSEQAHGVP FSPEEPLLEP
   481  QAPGTPSSPF SPPSGHQPVS DWGEEVELNS PRTTHLAGAL SPGEAWPFES V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

pancreas: 51 nTPM
testis: 40 nTPM
bone marrow: 38 nTPM
skin: 36 nTPM
blood vessel: 33 nTPM
ovary: 32 nTPM

Single-cell type

late spermatids: 723 nCPM
early spermatids: 164 nCPM
neutrophils: 52 nCPM
retinal pigment epithelial cells: 43 nCPM
syncytiotrophoblasts: 27 nCPM
undifferentiated spermatogonia: 27 nCPM

Immune cell

neutrophil: 3.6 nTPM
eosinophil: 2 nTPM
T-reg: 1.9 nTPM
intermediate monocyte: 1.4 nTPM
plasmacytoid DC: 1.4 nTPM
gdT-cell: 1.3 nTPM

Brain region

choroid plexus: 36 nTPM
medulla oblongata: 34 nTPM
cerebral cortex: 27 nTPM
thalamus: 27 nTPM
hippocampal formation: 26 nTPM
white matter: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0
gnomAD missense Z: -0.18
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Cellular components

exon-exon junction complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC9 as an antibody target. Whether an autoantibody or antibody against CCDC9 could matter depends on whether native CCDC9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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