Seroatlas · Human Serome Atlas

CCDC89

Coiled-coil domain-containing protein 89

Also known as: CCD89_HUMAN, FLJ38159

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N998
Gene: CCDC89
Ensembl: ENSG00000179071
Chromosome: 11
Canonical length: 374 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>Q8N998|CCDC89
     1  MRAPMLQKQQ APRMDTPPPE ERLEKQNEKL NNQEEETEFK ELDGLREALA NLRGLSEEER
    61  SEKAMLRSRI EEQSQLICIL KRRSDEALER CQILELLNAE LEEKMMQEAE KLKAQGEYSR
   121  KLEERFMTLA ANHELMLRFK DEYKSENIKL REENEKLRLE NSSLFSQALK DEEAKVLQLT
   181  VRCEALTGEL ETLKERCAQD ACQAQAREKE LLELQSQQAC THTKETEQLR SQLQTLKQQH
   241  QQAVEQIAKA EETHSSLSQE LQARLQTVTR EKEELLQLSI ERGKVLQNKQ AEICQLEEKL
   301  EIANEDRKHA LERFEQEAVA VDSNLRVREL QRKVDGIQKA YDELRLQSEA FKKHSLDLLS
   361  KERELNGKLR HLSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC89 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

testis: 24 nTPM
fallopian tube: 7.3 nTPM
ovary: 4.1 nTPM
endometrium: 2.4 nTPM
retina: 1.5 nTPM
seminal vesicle: 1.4 nTPM

Single-cell type

early spermatids: 433 nCPM
late primary spermatocytes: 364 nCPM
fallopian tube ciliated cells: 49 nCPM
respiratory ciliated cells: 39 nCPM
late spermatids: 31 nCPM
ependymal cells: 12 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 3.3 nTPM
midbrain: 3 nTPM
cerebellum: 2.7 nTPM
spinal cord: 2.6 nTPM
white matter: 2.1 nTPM
choroid plexus: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: 0.06
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 89-like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC89 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HEY1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC89 as an antibody target. Whether an autoantibody or antibody against CCDC89 could matter depends on whether native CCDC89 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC89 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC89 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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