Seroatlas · Human Serome Atlas

CCDC88B

Coiled-coil domain-containing protein 88B

Also known as: BRLZ, CC88B_HUMAN, CCDC88, FLJ00354, FLJ37970, GIPIE, HkRP3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NC98
Gene: CCDC88B
Ensembl: ENSG00000168071
Chromosome: 11
Canonical length: 1476 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the hook-related protein family. Members of this family are characterized by an N-terminal potential microtubule binding domain, a central coiled-coiled and a C-terminal Hook-related domain. The encoded protein may be involved in linking organelles to microtubules. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

1476 residues, UniProt reviewed canonical sequence.

>A6NC98|CCDC88B
     1  MEGGKGPRLR DFLSGSLATW ALGLAGLVGE AEDSEGEEEE EEEEPPLWLE KRFLRLSDGA
    61  LLLRVLGIIA PSSRGGPRML RGLDGPAAWR VWNLNHLWGR LRDFYQEELQ LLILSPPPDL
   121  QTLGFDPLSE EAVEQLEGVL RLLLGASVQC EHRELFIRHI QGLSLEVQSE LAAAIQEVTQ
   181  PGAGVVLALS GPDPGELAPA ELEMLSRSLM GTLSKLARER DLGAQRLAEL LLEREPLCLR
   241  PEAPSRAPAE GPSHHLALQL ANAKAQLRRL RQELEEKAEL LLDSQAEVQG LEAEIRRLRQ
   301  EAQALSGQAK RAELYREEAE ALRERAGRLP RLQEELRRCR ERLQAAEAYK SQLEEERVLS
   361  GVLEASKALL EEQLEAARER CARLHETQRE NLLLRTRLGE AHAELDSLRH QVDQLAEENV
   421  ELELELQRSL EPPPGSPGEA PLAGAAPSLQ DEVREAEAGR LRTLERENRE LRGLLQVLQG
   481  QPGGQHPLLE APREDPVLPV LEEAPQTPVA FDHSPQGLVQ KARDGGPQAL DLAPPALDSV
   541  LEASAECPQA PDSDPQEAES PLQAAAMDPQ ASDWSPQESG SPVETQESPE KAGRRSSLQS
   601  PASVAPPQGP GTKIQAPQLL GGETEGREAP QGELVPEAWG LRQEGPEHKP GPSEPSSVQL
   661  EEQEGPNQGL DLATGQAEAR EHDQRLEGTV RDPAWQKPQQ KSEGALEVQV WEGPIPGESL
   721  ASGVAEQEAL REEVAQLRRK AEALGDELEA QARKLEAQNT EAARLSKELA QARRAEAEAH
   781  REAEAQAWEQ ARLREAVEAA GQELESASQE REALVEALAA AGRERRQWER EGSRLRAQSE
   841  AAEERMQVLE SEGRQHLEEA ERERREKEAL QAELEKAVVR GKELGDRLEH LQRELEQAAL
   901  ERQEFLREKE SQHQRYQGLE QRLEAELQAA ATSKEEALME LKTRALQLEE ELFQLRQGPA
   961  GLGPKKRAEP QLVETQNVRL IEVERSNAML VAEKAALQGQ LQHLEGQLGS LQGRAQELLL
  1021  QSQRAQEHSS RLQAEKSVLE IQGQELHRKL EVLEEEVRAA RQSQEETRGQ QQALLRDHKA
  1081  LAQLQRRQEA ELEGLLVRHR DLKANMRALE LAHRELQGRH EQLQAQRASV EAQEVALLAE
  1141  RERLMQDGHR QRGLEEELRR LQSEHDRAQM LLAELSRERG ELQGERGELR GRLARLELER
  1201  AQLEMQSQQL RESNQQLDLS ACRLTTQCEL LTQLRSAQEE ENRQLLAEVQ ALSRENRELL
  1261  ERSLESRDHL HREQREYLDQ LNALRREKQK LVEKIMDQYR VLEPVPLPRT KKGSWLADKV
  1321  KRLMRPRREG GPPGGLRLGA DGAGSTESLG GPPETELPEG READGTGSPS PAPMRRAQSS
  1381  LCLRDETLAG GQRRKLSSRF PVGRSSESFS PGDTPRQRFR QRHPGPLGAP VSHSKGPGVG
  1441  WENSAETLQE HETDANREGP EVQEPEKRPL TPSLSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC88B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 85 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 85 nTPM
spleen: 84 nTPM
bone marrow: 45 nTPM
small intestine: 32 nTPM
lymph node: 27 nTPM
lung: 21 nTPM

Single-cell type

neutrophils: 177 nCPM
neutrophil progenitors: 173 nCPM
tuft cells: 104 nCPM
foveolar cells: 79 nCPM
monocyte progenitors: 48 nCPM
microglia: 47 nCPM

Immune cell

neutrophil: 9.2 nTPM
eosinophil: 6.7 nTPM
NK-cell: 6.5 nTPM
classical monocyte: 4.6 nTPM
intermediate monocyte: 3.7 nTPM
gdT-cell: 3.5 nTPM

Brain region

cerebellum: 14 nTPM
pons: 8.6 nTPM
medulla oblongata: 5.6 nTPM
white matter: 5.4 nTPM
midbrain: 4.7 nTPM
spinal cord: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0
gnomAD missense Z: 0.94
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC88B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC88B as an antibody target. Whether an autoantibody or antibody against CCDC88B could matter depends on whether native CCDC88B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC88B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC88B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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