Seroatlas · Human Serome Atlas

CCDC87

Coiled-coil domain-containing protein 87

Also known as: CCD87_HUMAN, FLJ10786

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NVE4
Gene: CCDC87
Ensembl: ENSG00000182791
Chromosome: 11
Canonical length: 849 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to be involved in positive regulation of acrosome reaction and positive regulation of fertilization. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

849 residues, UniProt reviewed canonical sequence.

>Q9NVE4|CCDC87
     1  MMEPPKPEPE LQRFYHRLLR PLSLFPTRTT SPEPQKRPPQ EGRILQSFPL AKLTVASLCS
    61  QVAKLLAGSG IAAGVPPEAR LRLIKVILDE LKCSWREPPA ELSLSHKNNQ KLRKRLEAYV
   121  LLSSEQLFLR YLHLLVTMST PRGVFTESAT LTRLAASLAR DCTLFLTSPN VYRGLLADFQ
   181  ALLRAEQASG DVDKLHPVCP AGTFKLCPIP WPHSTGFAQV QCSNLNLNYL IQLSRPPEFL
   241  NEPGRMDPVK ELKSIPRLKR KKPFHWLPSI GKKREIDISS SQMVSLPSYP VAPTSRASPS
   301  PFCPELRRGQ SMPSLREGWR LADELGLPPL PSRPLTPLVL ATESKPELTG LIVAEDLKQL
   361  IKKMKLEGTR YPPLDSGLPP LLGVVTRHPA AGHRLEELEK MLRNLQEEEA SGQWDPQPPK
   421  SFPLHPQPVT ITLKLRNEVV VQAAAVRVSD RNFLDSFHIE GAGALYNHLA GELDPKAIEK
   481  MDIDNFVGST TREVYKELMS HVSSDHLHFD QGPLVEPAAD KDWSTFLSSA FLRQEKQPQI
   541  INPELVGLYS QRANTLQSNT KKMPSLPSLQ ATKSWEKWSN KASLMNSWKT TLSVDDYFKY
   601  LTNHETDFLH VIFQMHEEEV PVEIVAPARE SLEIQHPPPL LEDEEPDFVP GEWDWNTVLE
   661  HRLGAGKTPH LGEPHKILSL QKHLEQLWSV LEVPDKDQVD MTIKYSSKAR LRQLPSLVNA
   721  WERALKPIQL REALLARLEW FEGQASNPNR FFKKTNLSSS HFLEENQVRS HLHRKLNLME
   781  SSLVSLLEEI ELIFGEPVIF KGRPYLDKMK SDKVEMLYWL QQQRRVRHLV SALKDPHQST
   841  LFRSSAASL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC87 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

testis: 13 nTPM
epididymis: 1.6 nTPM
retina: 1.3 nTPM
parathyroid gland: 1.1 nTPM
thyroid gland: 0.8 nTPM
pituitary gland: 0.4 nTPM

Single-cell type

late primary spermatocytes: 45 nCPM
early spermatids: 26 nCPM
early primary spermatocytes: 7.2 nCPM
megakaryocytes: 6.2 nCPM
late spermatids: 5.2 nCPM
cardiomyocytes: 2.3 nCPM

Immune cell

plasmacytoid DC: 0.3 nTPM
non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 1.6 nTPM
hypothalamus: 1.4 nTPM
basal ganglia: 1.3 nTPM
cerebral cortex: 1.2 nTPM
hippocampal formation: 1.2 nTPM
amygdala: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
gnomAD missense Z: -0.02
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

Microtubule associated protein (MAP65/ASE1 family)
Coiled-coil domain-containing protein 87

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC87 as an antibody target. Whether an autoantibody or antibody against CCDC87 could matter depends on whether native CCDC87 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC87 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC87 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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