Seroatlas · Human Serome Atlas

CCDC83

Coiled-coil domain-containing protein 83

Also known as: CCD83_HUMAN, CT148, FLJ42119, KP-CoT-23, MGC34732

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWF9
Gene: CCDC83
Ensembl: ENSG00000150676
Chromosome: 11
Canonical length: 413 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

No narrative summary is available for CCDC83 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

413 residues, UniProt reviewed canonical sequence.

>Q8IWF9|CCDC83
     1  MENSGKANKK DTHDGPPKEI KLPTSEALLD YQCQIKEDAV EQFMFQIKTL RKKNQKYHER
    61  NSRLKEEQIW HIRHLLKELS EEKAEGLPVV TREDVEEAMK EKWKFERDQE KNLRDMRMQI
   121  SNAEKLFLEK LSEKEYWEEY KNVGSERHAK LITSLQNDIN TVKENAEKMS EHYKITLEDT
   181  RKKIIKETLL QLDQKKEWAT QNAVKLIDKG SYLEIWENDW LKKEVAIHRK EVEELKNAIH
   241  ELEAENLVLI DQLSNCRLVD LKIPRRLYLT QAAGLEVPPE EMSLELPETH IEEKSELQPT
   301  EVESRDLMSS SDESTILHLS HENSIEDLQY VKIDKEENSG TEFGDTDMKY LLYEDEKDFK
   361  DYVNLGPLGV KLMSVESKKM PIHFQEKEIP VKLYKDVRSP ESHITYKMMK SFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC83 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

testis: 33 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late primary spermatocytes: 449 nCPM
late spermatids: 316 nCPM
early spermatids: 180 nCPM
early primary spermatocytes: 19 nCPM
epicardial cells: 14 nCPM
neuroendocrine cells: 9.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.9 nTPM
amygdala: 0.4 nTPM
pons: 0.4 nTPM
white matter: 0.4 nTPM
basal ganglia: 0.3 nTPM
cerebellum: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
gnomAD missense Z: -0.45
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 83

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC83 as an antibody target. Whether an autoantibody or antibody against CCDC83 could matter depends on whether native CCDC83 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC83 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC83 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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