Seroatlas · Human Serome Atlas

CCDC82

Coiled-coil domain-containing protein 82

Also known as: CCD82_HUMAN, FLJ23518

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N4S0
Gene: CCDC82
Ensembl: ENSG00000149231
Chromosome: 11
Canonical length: 544 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

544 residues, UniProt reviewed canonical sequence.

>Q8N4S0|CCDC82
     1  MIHVRRHETR RNSKSHVPEQ KSRVDWRRTK RSSISQLLDS DEELDSEEFD SDEELDSDES
    61  FENDEELDSN KGPDCNKTPG SERELNLSKI QSEGNDSKCL INSGNGSTYE EETNKIKHRN
   121  IDLQDQEKHL SQEDNDLNKQ TGQIIEDDQE KHLSQEDNDL NKQTGQIIED DLEEEDIKRG
   181  KRKRLSSVMC DSDESDDSDI LVRKVGVKRP RRVVEDEGSS VEMEQKTPEK TLAAQKREKL
   241  QKLKELSKQR SRQRRSSGRD FEDSEKESCP SSDEVDEEEE EDNYESDEDG DDYIIDDFVV
   301  QDEEGDEENK NQQGEKLTTS QLKLVKQNSL YSFSDHYTHF ERVVKALLIN ALDESFLGTL
   361  YDGTRQKSYA KDMLTSLHYL DNRFVQPRLE SLVSRSRWKE QYKERVENYS NVSIHLKNPE
   421  NCSCQACGLH RYCKYSVHLS GELYNTRTMQ IDNFMSHDKQ VFTVGRICAS RTRIYHKLKH
   481  FKFKLYQECC TIAMTEEVED EQVKETVERI FRRSKENGWI KEKYGQLEEY LNFADYFQEE
   541  KFEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC82 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

retina: 40 nTPM
cerebellum: 31 nTPM
spinal cord: 24 nTPM
midbrain: 22 nTPM
testis: 22 nTPM
hippocampal formation: 22 nTPM

Single-cell type

early spermatids: 500 nCPM
late primary spermatocytes: 484 nCPM
oligodendrocytes: 144 nCPM
cone photoreceptor cells: 141 nCPM
early primary spermatocytes: 96 nCPM
respiratory ciliated cells: 92 nCPM

Immune cell

basophil: 60 nTPM
NK-cell: 36 nTPM
T-reg: 29 nTPM
naive CD4 T-cell: 27 nTPM
naive CD8 T-cell: 26 nTPM
eosinophil: 25 nTPM

Brain region

cerebellum: 96 nTPM
white matter: 92 nTPM
cerebral cortex: 82 nTPM
hypothalamus: 82 nTPM
pons: 71 nTPM
basal ganglia: 70 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCDC82.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 108 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual disability
CCDC82-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0
gnomAD missense Z: 0.08
DepMap mean gene effect: 0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

Domain of unknown function DUF4211
Domain of unknown function (DUF4211)
Coiled-coil domain-containing protein 82
Domain of unknown function (DUF4196)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC82 as an antibody target. Whether an autoantibody or antibody against CCDC82 could matter depends on whether native CCDC82 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC82 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC82 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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