Seroatlas · Human Serome Atlas

CCDC81

Coiled-coil domain-containing protein 81

Also known as: CCD81_HUMAN, FLJ16339, FLJ23514

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZN84
Gene
CCDC81
Ensembl
ENSG00000149201
Chromosome
11
Canonical length
652 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Basal body

OverviewNCBI Gene

Located in centrosome; ciliary basal body; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

652 residues, UniProt reviewed canonical sequence.

>Q6ZN84|CCDC81
     1  MLDTIARALQ DLGRQVLPTL PSLSQEEVSI IWGNVSEFVR RQLTLHKGVQ IPAFGTFTFI
    61  RQKLEVGNNK FILIQRPVFI MVEKLVQIHG LKQNKVYTPG EIPIVPLNFV MISLEGPFNR
   121  DVVEGCVKET LLFLSRSISM KQNVEFTFKG IGVLMIRDSK VKMRFYKDFL CTMDGSGALA
   181  KALANRPGTV DSVLSSREAL RKWPSSVLAF PRIELKEMEN KLPMETLVEE CGENRERKCK
   241  LKDQSDKEEG TRDISSPKRL RDRQALFPAK VTNVSLLEKF ERSESGGKIM TPESLSYPSC
   301  LKHDSEMKPQ TSPACQDHNK AGQEMCYVCL QRAQRNSLLY YSEERRREIE DERLIQQYQM
   361  LKDQEALFRH QMKSLATREQ NQKNAAYNLG VAEAIRNHKN EKPEFYKSFL FDKRPLSPAL
   421  NALKQEEYSR SLLKQMDNRQ ENEIKQRQYR ELMDRLEQVQ LTEELAAQRA KFLKDKMEET
   481  QCYKRALDAQ IKNKPSRLPP FEPDSSEPIF GKNEGELMVE KQKREQNYMK HQLEAAANHK
   541  RKAILHQLVD QRRDLQMLQR TQREHLADRT AELERVNRVN QCLQEDWERS AAMKKQRDLE
   601  DKAFERASDK LFLLDQCEKY RRCKQCQRRT SNVGESNLWP LNKFLPGSRL LV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC81 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 26 nTPM
  • choroid plexus: 16 nTPM
  • testis: 5.4 nTPM
  • blood vessel: 3.3 nTPM
  • cervix: 1.8 nTPM
  • pituitary gland: 1.7 nTPM

Single-cell type

  • ependymal cells: 198 nCPM
  • fallopian tube ciliated cells: 139 nCPM
  • respiratory ciliated cells: 124 nCPM
  • endometrial ciliated cells: 116 nCPM
  • pituitary stem cells: 113 nCPM
  • late primary spermatocytes: 55 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 21 nTPM
  • midbrain: 11 nTPM
  • medulla oblongata: 8.2 nTPM
  • spinal cord: 6.7 nTPM
  • hypothalamus: 4.5 nTPM
  • pons: 4.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
0.43
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Coiled-coil domain-containing protein 81
  • CCDC81, HU domain 1
  • CCDC81, HU domain 2
  • CCDC81 eukaryotic HU domain 1
  • CCDC81 eukaryotic HU domain 2

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC81 as an antibody target. Whether an autoantibody or antibody against CCDC81 could matter depends on whether native CCDC81 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC81 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC81 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC81. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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