Seroatlas · Human Serome Atlas

CCDC78

Coiled-coil domain-containing protein 78

Also known as: C16orf25, CCD78_HUMAN, FLJ34512

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A2IDD5
Gene
CCDC78
Ensembl
ENSG00000162004
Chromosome
16
Canonical length
438 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

Involved in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation and skeletal muscle contraction. Located in several cellular components, including centriole; deuterosome; and sarcolemma. Implicated in centronuclear myopathy 4. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

438 residues, UniProt reviewed canonical sequence.

>A2IDD5|CCDC78
     1  MEHAATTGPR PGPPSRRVEN VVLRAKDWLP GAPGGTAVWA TSLEAEVPPD LALNKEQQLQ
    61  ISKELVDIQI TTHHLHEQHE AEIFQLKSEI LRLESRVLEL ELRGDGTSQG CAVPVESDPR
   121  HPRAAAQELR HKAQVPGHSD DHRFQVQPKN TMNPENEQHR LGSGLQGEVK WALEHQEARQ
   181  QALVTRVATL GRQLQGAREE ARAAGQRLAT QAVVLCSCQG QLRQAEAENA RLQLQLKKLK
   241  DEYVLRLQHC AWQAVEHADG AGQAPATTAL RTFLEATLED IRAAHRSREQ QLARAARSYH
   301  KRLVDLSRRH EELLVAYRAP GNPQAIFDIA SLDLEPLPVP LVTDFSHRED QHGGPGALLS
   361  SPKKRPGGAS QGGTSEPQGL DAASWAQIHQ KLRDFSRSTQ SWNGSGHSCW SGPRWLKSNF
   421  LSYRSTWTST WAGTSTKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC78 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 28 nTPM
  • basal ganglia: 11 nTPM
  • cerebellum: 8.6 nTPM
  • lung: 7.6 nTPM
  • choroid plexus: 6.5 nTPM
  • hypothalamus: 5.9 nTPM

Single-cell type

  • respiratory ciliated cells: 426 nCPM
  • epididymal efferent duct ciliated cells: 338 nCPM
  • fallopian tube ciliated cells: 319 nCPM
  • endometrial ciliated cells: 211 nCPM
  • ependymal cells: 132 nCPM
  • brain inhibitory neurons: 9.8 nCPM

Immune cell

  • memory CD8 T-cell: 0.6 nTPM
  • MAIT T-cell: 0.3 nTPM
  • eosinophil: 0.2 nTPM
  • NK-cell: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • midbrain: 14 nTPM
  • medulla oblongata: 14 nTPM
  • spinal cord: 7.9 nTPM
  • cerebellum: 6.9 nTPM
  • pons: 6.8 nTPM
  • cerebral cortex: 5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCDC78.

Disease | AllUniProt

Conditions CCDC78 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.79
gnomAD pLI
0
gnomAD missense Z
-0.86
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Domain of unknown function DUF4472
  • Coiled-coil domain-containing protein 78
  • Domain of unknown function (DUF4472)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC78 as an antibody target. Whether an autoantibody or antibody against CCDC78 could matter depends on whether native CCDC78 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC78 is annotated at the cell surface, where native CCDC78 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CCDC78 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC78. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...