Seroatlas · Human Serome Atlas

CCDC77

Coiled-coil domain-containing protein 77

Also known as: CCD77_HUMAN, MGC13183

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BR77
Gene: CCDC77
Ensembl: ENSG00000120647
Chromosome: 12
Canonical length: 488 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear membrane

OverviewNCBI Gene

Located in centrosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

488 residues, UniProt reviewed canonical sequence.

>Q9BR77|CCDC77
     1  MNFTPTHTPV CRKRTVVSKR GVAVSGPTKR RGMADSLEST PLPSPEDRLA KLHPSKELLE
    61  YYQKKMAECE AENEDLLKKL ELYKEACEGQ HKLECDLQQR EEEIAELQKA LSDMQVCLFQ
   121  EREHVLRLYS ENDRLRIREL EDKKKIQNLL ALVGTDAGEV TYFCKEPPHK VTILQKTIQA
   181  VGECEQSESS AFKADPKISK RRPSRERKES SEHYQRDIQT LILQVEALQA QLGEQTKLSR
   241  EQIEGLIEDR RIHLEEIQVQ HQRNQNKIKE LTKNLHHTQE LLYESTKDFL QLRSENQNKE
   301  KSWMLEKDNL MSKIKQYRVQ CKKKEDKIGK VLPVMHESHH AQSEYIKSLK DKLVQEKKLS
   361  NMYQEQCISL EEELARIREE EGMRREIFKD RTNKMGKRLQ IMTKRYEALE RRRILEVEGF
   421  KTDIKVLRQK LKDLEQMLYK ATVNARANQD LALLCEVRDS NRRAHKIQGE LKNLKSKVFG
   481  LENELRLC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC77 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

testis: 12 nTPM
thymus: 9 nTPM
lymph node: 6.4 nTPM
spinal cord: 6.3 nTPM
appendix: 5.8 nTPM
tonsil: 5.8 nTPM

Single-cell type

cardiomyocytes: 95 nCPM
late primary spermatocytes: 45 nCPM
early spermatids: 43 nCPM
differentiating spermatogonia: 41 nCPM
undifferentiated spermatogonia: 41 nCPM
erythrocyte progenitors: 34 nCPM

Immune cell

naive B-cell: 8.2 nTPM
non-classical monocyte: 8.1 nTPM
intermediate monocyte: 6.4 nTPM
NK-cell: 6.2 nTPM
memory B-cell: 5.9 nTPM
memory CD8 T-cell: 5.2 nTPM

Brain region

white matter: 19 nTPM
basal ganglia: 14 nTPM
cerebral cortex: 13 nTPM
medulla oblongata: 13 nTPM
hypothalamus: 13 nTPM
midbrain: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: 0.31
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 77

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC77 as an antibody target. Whether an autoantibody or antibody against CCDC77 could matter depends on whether native CCDC77 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC77 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC77 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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