Seroatlas · Human Serome Atlas

CCDC74B

Coiled-coil domain-containing protein 74B

Also known as: CC74B_HUMAN, DKFZp434E2321

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LY2
Gene: CCDC74B
Ensembl: ENSG00000152076
Chromosome: 2
Canonical length: 380 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome,Basal body,Cytosol

OverviewNCBI Gene

No narrative summary is available for CCDC74B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

380 residues, UniProt reviewed canonical sequence.

>Q96LY2|CCDC74B
     1  MSGAGVAAGT RPPSSPTPGS RRRRQRPSVG VQSLRPQSPQ LRQSDPQKRN LDLEKSLQFL
    61  QQQHSEMLAK LHEEIEHLKR ENKDLRYKLI MNQTSQKKDG PSGNHLSRAS APLGARWVCI
   121  NGVWVEPGGP SPARLKEGSS RTHRPGGKHG RLAGGSADTV RSPADSLSTS SFQSVKSISN
   181  SGKARPQPGS FNKQDSKADV PQKADLEEEP LLHNSKLDKV PGVQGQARKE KAEASNAGAA
   241  CMGNSQHQGR QMGAAAHPPM ILPLPLRKPT TLRQCEVLIR ELWNTNLLQT QELQHLKSLL
   301  EGSQRPQAVP EEASFPRDQE ATHFPKVSTK SLSKKCLLLS PPVAERAILP ALKQTPKNNF
   361  AERQKRLQAM QKRRLHRSVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC74B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

testis: 51 nTPM
pituitary gland: 19 nTPM
cervix: 15 nTPM
fallopian tube: 13 nTPM
parathyroid gland: 10 nTPM
hypothalamus: 9.9 nTPM

Single-cell type

late primary spermatocytes: 351 nCPM
early spermatids: 304 nCPM
late spermatids: 177 nCPM
respiratory ciliated cells: 122 nCPM
fallopian tube ciliated cells: 115 nCPM
epididymal efferent duct ciliated cells: 114 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 14 nTPM
midbrain: 14 nTPM
medulla oblongata: 11 nTPM
hypothalamus: 11 nTPM
spinal cord: 9.7 nTPM
hippocampal formation: 6.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
gnomAD missense Z: -0.67
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC74B as an antibody target. Whether an autoantibody or antibody against CCDC74B could matter depends on whether native CCDC74B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC74B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC74B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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