Seroatlas · Human Serome Atlas

CCDC74A

Coiled-coil domain-containing protein 74A

Also known as: CC74A_HUMAN, FLJ40345

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96AQ1
Gene: CCDC74A
Ensembl: ENSG00000163040
Chromosome: 2
Canonical length: 378 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome,Basal body,Cytosol

OverviewNCBI Gene

No narrative summary is available for CCDC74A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

378 residues, UniProt reviewed canonical sequence.

>Q96AQ1|CCDC74A
     1  MSGAGVAAGT RPPSSPTPGS RRRRQRPSVG VQSLRPQSPQ LRQSDPQKRN LDLEKSLQFL
    61  QQQHSEMLAK LHEEIEHLKR ENKDLHYKLI MNQTSQKKDG PSGNHLSRAS APLGARWVCI
   121  NGVWVEPGGP SPARLKEGSS RTHRPGGKRG RLAGGSADTV RSPADSLSMS SFQSVKSISN
   181  SGKARPQPGS FNKQDSKADV SQKADLEEEP LLHNSKLDKV PGVQGQARKE KAEASNAGAA
   241  CMGNSQHQGR QMGAGAHPPM ILPLPLRKPT TLRQCEVLIR ELWNTNLLQT QELRHLKSLL
   301  EGSQRPQAAP EEASFPRDQE ATHFPKVSTK SLSKKCLSPP VAERAILPAL KQTPKNNFAE
   361  RQKRLQAMQK RRLHRSVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC74A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 71 nTPM

Expression across tissuesHPA

Tissue

testis: 71 nTPM
choroid plexus: 63 nTPM
pituitary gland: 34 nTPM
fallopian tube: 33 nTPM
adrenal gland: 32 nTPM
parathyroid gland: 19 nTPM

Single-cell type

late spermatids: 414 nCPM
early spermatids: 407 nCPM
late primary spermatocytes: 397 nCPM
epididymal efferent duct ciliated cells: 203 nCPM
respiratory ciliated cells: 202 nCPM
fallopian tube ciliated cells: 176 nCPM

Immune cell

myeloid DC: 0.8 nTPM
memory CD4 T-cell: 0.2 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

choroid plexus: 53 nTPM
hypothalamus: 21 nTPM
midbrain: 17 nTPM
medulla oblongata: 16 nTPM
hippocampal formation: 13 nTPM
spinal cord: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
gnomAD missense Z: -0.22
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC74A as an antibody target. Whether an autoantibody or antibody against CCDC74A could matter depends on whether native CCDC74A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC74A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC74A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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