Seroatlas · Human Serome Atlas

CCDC73

Coiled-coil domain-containing protein 73

Also known as: CCD73_HUMAN, NY-SAR-79

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZRK6
Gene: CCDC73
Ensembl: ENSG00000186714
Chromosome: 11
Canonical length: 1079 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CCDC73 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1079 residues, UniProt reviewed canonical sequence.

>Q6ZRK6|CCDC73
     1  MESNFNTESS STFTLQSSSE TLFSIQLLDF KTSLLEALEE LRMRREAEIH YEEQIGKIIV
    61  ETQELKWQKE TLQNQKETLA EQHKEAMAVF KKQLQMKMCA LEEEKGKYQL ATEIKEKEIE
   121  GLKETLKALQ VSKYSLQKKV SEMEQKVQLH LLAKEDYHKQ LSEIEKYYAT ITGQFGLVKE
   181  NHEKLEQNVR EAIQSNKRLS ALNKKQEAEI CSLKKELKKA ASDLIKSKVT CQYKMGEENI
   241  NLTIKEQKFQ ELQERLNMEL ELNEKINEEI THIQEEKQDI IISFQHMQQL LRQQIQANTE
   301  MEAELKVLKE NNQTLERDNE LQREKVKENE EKFLNLQNEH EKALGTWKRH AEELNGEINK
   361  IKNELSSLKE THIKLQEHYN KLCNQKTFEE DKKFQNVPEV NNENSEMSTE KSENTIIQKY
   421  NTEQEIREEN MENFCSDTEY REKEEKKEGS FIEEIIIDDL QLFEKSFKNE IDTVVSQDEN
   481  QSEISLSKTL SLDKEVISQG QTSNVTDNRK SVTTEIKDKI CLEKDNGCTE FKSPNNHFVV
   541  LDTAIETEKI HLERTRGLDV HHTDVNLEVE NNKTSFNSIL NETAHNTYHN NNKDVSENEP
   601  FKQFRLLPGT REHALEKEIT NSDQTKADLD SSLDIKKNPV PCQKYSLRNS SNVMLDDKQC
   661  KIKQIQLLTK KSECSILLSK QTSDFLQVCN DTLEKSELTV PCDIVIDHHV SYAAFSANSK
   721  LLLKNSDKNV HSMSMLVKPN SSPGGKTMCK NMSDMQNSQF NNCLGYLENT NVNISHLHLN
   781  NENSHASQAK DVKTAVHMKT CTETEFSNKK NQIDENQVTE ATKNDLFLFV SINERQHTLL
   841  NNTEKTESLN DIVSGKMFSE GQLEESHSFH IEPSGDLVNR SGRSTFDLST SDKKTEKTPV
   901  YMNFSDPGPW SKVNHIESQT ASSSTPCISL LLKERPLDPS ENKKIISMAL CKNIGVDDVG
   961  KDIGPDTTSI NRVADTLNNW SIHPDPKGEP SEEKNAMAKT FYDSSFPTEH VKTKPLISTP
  1021  LQSHLQAIKT TKNTSGDDDW QSLITNQLNK SENLLSLEND NQPKKRKAEE TLEKNNRLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC73 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 3.5 nTPM

Expression across tissuesHPA

Tissue

testis: 3.5 nTPM
ovary: 0.5 nTPM
liver: 0.4 nTPM
cerebellum: 0.3 nTPM
spleen: 0.3 nTPM
adrenal gland: 0.2 nTPM

Single-cell type

early primary spermatocytes: 440 nCPM
differentiating spermatogonia: 134 nCPM
undifferentiated spermatogonia: 76 nCPM
oocytes: 55 nCPM
endometrial ciliated cells: 54 nCPM
adrenal medulla cells: 32 nCPM

Immune cell

naive B-cell: 0.3 nTPM
intermediate monocyte: 0.2 nTPM
non-classical monocyte: 0.2 nTPM
neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 1 nTPM
cerebellum: 0.7 nTPM
medulla oblongata: 0.6 nTPM
basal ganglia: 0.5 nTPM
hypothalamus: 0.5 nTPM
midbrain: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0
gnomAD missense Z: 0.88
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 73
Coiled-coil domain-containing protein 73 family

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC73 as an antibody target. Whether an autoantibody or antibody against CCDC73 could matter depends on whether native CCDC73 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC73 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC73 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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