Seroatlas · Human Serome Atlas

CCDC71L

Coiled-coil domain-containing protein 71L

Also known as: C7orf74, CC71L_HUMAN, FLJ36031

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9Z2
Gene: CCDC71L
Ensembl: ENSG00000253276
Chromosome: 7
Canonical length: 235 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Actin filaments,Cytosol

OverviewNCBI Gene

No narrative summary is available for CCDC71L in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

235 residues, UniProt reviewed canonical sequence.

>Q8N9Z2|CCDC71L
     1  MRRSMKRRRR RRPVAPATAA RGGDFRAEDG AGLEAREEKV VYSRSQLSLA DSTKALGDAF
    61  KLFMPRSTEF MSSDAELWSF LCSLKHQFSP HILRSKDVYG YSSCRALVPD PPGPPTARGQ
   121  ARRPVPRAAA RRRRRGARAA AARRRKPRPP PPPPPPPEES CPAKPVAPGP CFGGRTLEEI
   181  WRAATPTLTT FPTIRVGSDV WGERSLAAAR RRARQVLRVN LEPMVRLRRF PVPRA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC71L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

urinary bladder: 18 nTPM
adipose tissue: 17 nTPM
liver: 14 nTPM
blood vessel: 9.7 nTPM
appendix: 9.1 nTPM
lung: 9.1 nTPM

Single-cell type

loop of henle epithelial cells: 8.6 nCPM
podocytes: 5.2 nCPM
papillary tip epithelial cells: 4.6 nCPM
renal collecting duct principal cells: 4.3 nCPM
proximal tubule cells: 2.1 nCPM
renal collecting duct intercalated cells: 2.1 nCPM

Immune cell

basophil: 1.1 nTPM
neutrophil: 1 nTPM
NK-cell: 0.5 nTPM
eosinophil: 0.4 nTPM
plasmacytoid DC: 0.4 nTPM
T-reg: 0.4 nTPM

Brain region

medulla oblongata: 7.7 nTPM
thalamus: 3.9 nTPM
white matter: 3.3 nTPM
hypothalamus: 3.2 nTPM
pons: 3.2 nTPM
spinal cord: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0.58
gnomAD missense Z: 1.03
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC71L as an antibody target. Whether an autoantibody or antibody against CCDC71L could matter depends on whether native CCDC71L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC71L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC71L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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