Seroatlas · Human Serome Atlas

CCDC71

Coiled-coil domain-containing protein 71

Also known as: CCD71_HUMAN, FLJ12800

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IV32
Gene: CCDC71
Ensembl: ENSG00000177352
Chromosome: 3
Canonical length: 467 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear membrane

OverviewNCBI Gene

No narrative summary is available for CCDC71 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

467 residues, UniProt reviewed canonical sequence.

>Q8IV32|CCDC71
     1  MSVVVQHVEE KAVHSWSRIS TAGKKALEEA LLVFNPMSQD LSATEAQLVA FLQGLRDDGF
    61  QPTILRSGDV YGYSSCTANP PSQTKLQARA PNPTATSPPA SAPRTAMRLP AGRATLLPMP
   121  LSGRLAKAST PALAKHATTN LLLSSLKQSS ASHARGAAVG FPTHLYPGVY PAMRLSVVLE
   181  ALVPLKTPMP CLGAKHKAQS LQLSLADSPL KLRKSSGKGP GNPRPKAPRK TTSKGPKCLT
   241  RKGPGAGPRR GSGHQSKTNR ATGSPSVRRM KGGSALGTKT AQAKVARTLA KAARAQAKVA
   301  RTQAKAAKAR AKAKAAQVKA KAKAKAAQVK AKAKVMAAWA KAKAKAKAVR AKAKVARTQP
   361  RGRGRPKGSA KARTTRKGQK NRPETVGQKR KRAEEAKDLP PKKRTRLGPR SPKAWLGPGT
   421  AKLLKFRAIK VDRRSSDDEV RQRAQRILRV NLSPVIRLQP LLPYSAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC71 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

ovary: 19 nTPM
fallopian tube: 15 nTPM
thyroid gland: 15 nTPM
adrenal gland: 15 nTPM
endometrium: 14 nTPM
skeletal muscle: 14 nTPM

Single-cell type

epididymal principal cells: 33 nCPM
decidual stromal cells: 29 nCPM
migrating cytotrophoblasts: 27 nCPM
cytotrophoblasts: 26 nCPM
syncytiotrophoblasts: 26 nCPM
hofbauer cells: 25 nCPM

Immune cell

NK-cell: 4.8 nTPM
intermediate monocyte: 1.7 nTPM
MAIT T-cell: 1.4 nTPM
naive B-cell: 1.3 nTPM
non-classical monocyte: 1.3 nTPM
memory CD8 T-cell: 1.2 nTPM

Brain region

hypothalamus: 12 nTPM
midbrain: 11 nTPM
medulla oblongata: 11 nTPM
spinal cord: 11 nTPM
basal ganglia: 11 nTPM
cerebellum: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0.03
gnomAD missense Z: -0.36
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC71 as an antibody target. Whether an autoantibody or antibody against CCDC71 could matter depends on whether native CCDC71 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC71 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC71 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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