Seroatlas · Human Serome Atlas

CCDC70

Coiled-coil domain-containing protein 70

Also known as: CCD70_HUMAN, DKFZP434K1172, FLJ25853

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6NSX1
Gene
CCDC70
Ensembl
ENSG00000123171
Chromosome
13
Canonical length
222 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

222 residues, UniProt reviewed canonical sequence.

>Q6NSX1|CCDC70
     1  MFSFKVSRWM GLACFRSLAA SSPSIRQKKL MHKLQEEKAF REEMKIFREK IEDFREEMWT
    61  FRGKIHAFRG QILGFWEEER PFWEEEKTFW KEEKSFWEME KSFREEEKTF WKKYRTFWKE
   121  DKAFWKEDNA LWERDRNLLQ EDKALWEEEK ALWVEERALL EGEKALWEDK TSLWEEENAL
   181  WEEERAFWME NNGHIAGEQM LEDGPHNANR GQRLLAFSRG RA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC70 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
127 nTPM

Expression across tissuesHPA

Tissue

  • testis: 127 nTPM
  • prostate: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • late spermatids: 4,602 nCPM
  • early spermatids: 1,109 nCPM
  • late primary spermatocytes: 334 nCPM
  • leydig cells: 5.2 nCPM
  • epicardial cells: 4.5 nCPM
  • epididymal clear cells: 4.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hippocampal formation: 2 nTPM
  • cerebral cortex: 1.7 nTPM
  • cerebellum: 1.2 nTPM
  • amygdala: 1.1 nTPM
  • basal ganglia: 1.1 nTPM
  • medulla oblongata: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.78
gnomAD pLI
0.01
gnomAD missense Z
-0.97
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC70 as an antibody target. Whether an autoantibody or antibody against CCDC70 could matter depends on whether native CCDC70 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC70 is annotated at the cell surface, where native CCDC70 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CCDC70 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC70. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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