Seroatlas · Human Serome Atlas

CCDC7

Coiled-coil domain-containing protein 7

Also known as: BIOT2, C10orf68, CCDC7_HUMAN, FLJ13031, FLJ32762

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96M83
Gene: CCDC7
Ensembl: ENSG00000216937
Chromosome: 10
Canonical length: 1385 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Mitotic spindle,Cytosol

OverviewNCBI Gene

No narrative summary is available for CCDC7 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1385 residues, UniProt reviewed canonical sequence.

>Q96M83|CCDC7
     1  MKPVKHLLTT SNKSANVPAL TTKKGLHNLP LSPELKEKHN AKLIHDKIEP MVLRSPPTGE
    61  SILRYALPIP SSKTKNLLPE DEMIGKIIKH LKMVVSTLEE TYGHCDQNGE EPFVKHEHEE
   121  LSLSVGDDMN SFLTYCSQFA AQLEEALKEE QNILESLFKW FQWQVNQMEE ISKDQTLLQA
   181  EPPKPDKTVI LNIAEIVRLV QRFEELKNRL KQRSKSSVKV MLSKTMDKEN RPEAVKSCEA
   241  LAQKIEEFLE AHSTDEFKDV SATEPQTAHS MTNRFNAMLK VFENQANMLE RAVNDQVLLD
   301  AEYKQMQCDF QLLSEEKLVL ENELQKLKDK EKTKPTNNRT KKAVKTVKKK DKGKSEDSEK
   361  KMSPEKEFKI KEDLDQVQKV ARLEIENKVL QEQLKQALQE AEKAKHQLNY FLNQEKLLKS
   421  EGKTETTMQV GNSQTKVKGE DSKNIPLEKE TRKSLVSDSG GQRTSDKIQE YPQITAQSGR
   481  LIEKSSEKKR SSPAISDLSQ ILKSQDESAF LESSNEVSVA ENQSYKSPSE THDKSLTTVS
   541  SSKEVQDSLS VGTLAQKNET VISPFILPPV LTESKKADVS EEQLQKMTEE QTYQAAEKSQ
   601  ADSEVPDENL MVENKDSVTK VQIEQMKQRT SSMERHEETL TTPQLPEDMV LVSRIQSETK
   661  NLKATRNESF HSHNDVPEEN LMLEQDTKSK TEVEVKKQKS FQDNQLSTHN EVPNERLVVE
   721  HQESLSKTKL QIKKQETSTE QPLTTPDKEP NENLILRHQD SMSKSEMQVK EQRTLKGQRI
   781  ITHDEEPGKN LVLEHQDSVS KLEMQIEKTK KLPREKRHST HDEESGENPM LKHQDSVSKI
   841  QVQLEIQETS EGEGRSIPDK NSMFVHQDSV SKLQMQEKKK ITPGRERRNT RIVVPNENVI
   901  SVHQDSKSKL QMQEKKQINS GVERHKTFPL EIKKKDISLE HLLPEEKVLL SRSESQTKKL
   961  QAKVTSRKIK NEAASELPDT AENLPAMYPS ISDLIIQFDL NKVVETDIES LRGALGRRLL
  1021  NDEFKTQSKS FPGPDIEQLT DAFGRDILKD EFKTRSKSLP ETDERLHSTT ERGTINDAIK
  1081  TQLKRKSYPE TVLKHLKGVN GKDIIKHLIN IQSKSHGETD KEHLADDTGR GIIKGSINAQ
  1141  LKGHQKTDKN FFAYATGRGL MKESTTTQLK SHPETDKEFL ADAIGRGIII GPITTQLKSH
  1201  RETDKELLKD AIGRDIIKGP ISAQLKSHQE TDVEPLTNAI GSSKTIGEIK TQLRTHYDVN
  1261  LFKNKDMSVQ RQEGIFTRSI TPSKFPTKVI NLSPFENKEE TYEYSSPYVT APSKAIYRTY
  1321  RAGPSFSKDI HLPLLNQLPS GHSKVVTLSQ KTIEFTLPTV TNTVGKPTYK VLHAAARKSV
  1381  PHPYF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

testis: 74 nTPM
retina: 2.5 nTPM
bone marrow: 1.6 nTPM
thyroid gland: 1.6 nTPM
lymph node: 1.4 nTPM
pancreas: 1.3 nTPM

Single-cell type

late spermatids: 2,170 nCPM
late primary spermatocytes: 697 nCPM
early spermatids: 691 nCPM
somatotrophs: 309 nCPM
thyrotrophs: 305 nCPM
lactotrophs: 295 nCPM

Immune cell

naive CD4 T-cell: 1.9 nTPM
memory CD4 T-cell: 1.8 nTPM
T-reg: 1.6 nTPM
MAIT T-cell: 1.4 nTPM
memory CD8 T-cell: 1.3 nTPM
naive CD8 T-cell: 1.2 nTPM

Brain region

cerebellum: 78 nTPM
white matter: 70 nTPM
basal ganglia: 62 nTPM
pons: 60 nTPM
thalamus: 59 nTPM
cerebral cortex: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 0.35
DepMap mean gene effect: 0.08
DepMap dependency class: none

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 7
Spermatogenesis family BioT2

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC7 as an antibody target. Whether an autoantibody or antibody against CCDC7 could matter depends on whether native CCDC7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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