Seroatlas · Human Serome Atlas

CCDC69

Coiled-coil domain-containing protein 69

Also known as: CCD69_HUMAN, DKFZP434C171, FLJ13705

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NI79
Gene: CCDC69
Ensembl: ENSG00000198624
Chromosome: 5
Canonical length: 296 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Plasma membrane,Actin filaments

OverviewNCBI Gene

Predicted to enable microtubule binding activity. Involved in spindle midzone assembly. Located in spindle midzone. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

296 residues, UniProt reviewed canonical sequence.

>A6NI79|CCDC69
     1  MGCRHSRLSS CKPPKKKRQE PEPEQPPRPE PHELGPLNGD TAITVQLCAS EEAERHQKDI
    61  TRILQQHEEE KKKWAQQVEK ERELELRDRL DEQQRVLEGK NEEALQVLRA SYEQEKEALT
   121  HSFREASSTQ QETIDRLTSQ LEAFQAKMKR VEESILSRNY KKHIQDYGSP SQFWEQELES
   181  LHFVIEMKNE RIHELDRRLI LMETVKEKNL ILEEKITTLQ QENEDLHVRS RNQVVLSRQL
   241  SEDLLLTREA LEKEVQLRRQ LQQEKEELLY RVLGANASPA FPLAPVTPTE VSFLAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC69 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 331 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 331 nTPM
tongue: 153 nTPM
colon: 145 nTPM
adipose tissue: 102 nTPM
urinary bladder: 97 nTPM
adrenal gland: 94 nTPM

Single-cell type

neutrophils: 348 nCPM
pdcs: 200 nCPM
monocytes: 155 nCPM
plasma cells: 147 nCPM
adrenal cortex cells: 137 nCPM
thymocytes: 122 nCPM

Immune cell

basophil: 31 nTPM
plasmacytoid DC: 19 nTPM
NK-cell: 14 nTPM
eosinophil: 14 nTPM
classical monocyte: 12 nTPM
total PBMC: 12 nTPM

Brain region

midbrain: 24 nTPM
pons: 23 nTPM
choroid plexus: 23 nTPM
medulla oblongata: 21 nTPM
cerebellum: 21 nTPM
spinal cord: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
gnomAD missense Z: -0.33
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

spindle midzone assembly

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Microtubule-associated tumor suppressor/Coiled-coil domain-containing protein 69

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC69 as an antibody target. Whether an autoantibody or antibody against CCDC69 could matter depends on whether native CCDC69 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC69 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC69 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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