Seroatlas · Human Serome Atlas

CCDC63

Coiled-coil domain-containing protein 63

Also known as: CCD63_HUMAN, FLJ35843, ODA5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NA47
Gene: CCDC63
Ensembl: ENSG00000173093
Chromosome: 12
Canonical length: 563 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cell Junctions,Principal piece

OverviewNCBI Gene

Predicted to be involved in cilium movement; outer dynein arm assembly; and spermatid development. Predicted to be active in axoneme. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

563 residues, UniProt reviewed canonical sequence.

>Q8NA47|CCDC63
     1  MSVLKKNRRK DSDTPQEPSE KAKEQQAEAE LRKLRQQFRK MVESRKSFKF RNQQKIASQY
    61  KEIKTLKTEQ DEITLLLSLM KSSRNMNRSE KNYMELRLLL QTKEDYEALI KSLKVLLAEL
   121  DEKILQMEKK IANQKQIFAK MQEANNPRKL QKQIHILETR LNLVTVHFDK MLTTNAKLRK
   181  EIEDLRFEKA AYDNVYQQLQ HCLLMEKKTM NLAIEQSSQA YEQRVEAMAR MAAMKDRQKK
   241  DTSQYNLEIR ELERLYAHES KLKSFLLVKL NDRNEFEEQA KREEALKAKK HVKKNRGESF
   301  ESYEVAHLRL LKLAESGNLN QLIEDFLAKE EKNFARFTYV TELNNDMEMM HKRTQRIQDE
   361  IILLRSQQKL SHDDNHSVLR QLEDKLRKTT EEADMYESKY GEVSKTLDLL KNSVEKLFKK
   421  INCDATKILV QLGETGKVTD INLPQYFAII EKKTNDLLLL ETYRRILEVE GAEAEIPPPF
   481  INPFWGGSAL LKPPEPIKVI PPVLGADPFS DRLDDVEQPL DHSSLRQLVL DNYILKENRS
   541  KEVRGDSLPE KVDDFRSRKK VTM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC63 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

testis: 17 nTPM
skeletal muscle: 2.5 nTPM
heart muscle: 1.4 nTPM
skin: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

early spermatids: 395 nCPM
late spermatids: 390 nCPM
late primary spermatocytes: 227 nCPM
myonuclei: 27 nCPM
oocytes: 18 nCPM
undifferentiated spermatogonia: 8.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: 0.23
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

axoneme

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC63 as an antibody target. Whether an autoantibody or antibody against CCDC63 could matter depends on whether native CCDC63 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC63 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC63 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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