Seroatlas · Human Serome Atlas

CCDC60

Coiled-coil domain-containing protein 60

Also known as: CCD60_HUMAN, MGC39827

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWA6
Gene: CCDC60
Ensembl: ENSG00000183273
Chromosome: 12
Canonical length: 550 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CCDC60 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

550 residues, UniProt reviewed canonical sequence.

>Q8IWA6|CCDC60
     1  MTKVPATKKL QSSPNSGAVR PFYASENLRQ VPDKPMKSIK YMDKEIINLK KDLIRSRFLI
    61  QSVKIGRGYF AILREETAKK KKQQQLQKLK EEERNKFQPA EKISEIHYGD TLLSTYDDEK
   121  LKTLGARVTR RPFTPIHSCI ISPSLTEAHV EPLFRQLCAL HWLLEALTID HTHHTMKPVI
   181  TCWNPKDPGG SKSTIKKINK DKSMGQKWEH FITAPKTKKF KIPTMRVTNR KPSRRGSTLS
   241  LSRASGGSSP QSSMISVNPG SDEPPSVNTQ VTSSKDIEDN ESSSTKPDEE PLYMNLQKLL
   301  EMVREDARRT VTIENGMQRK APSILSVLKQ NKSNSAYKEM QTTLKSSERS SSTSAESHIQ
   361  PVQKKSKNRT NCDINIHYKS GVCNTMRAKF YSVAQEAGFC LQDKMEILMK RQEERGIQKF
   421  RAFVLVSNFQ KDIAKMRHHI SVVKGDAEEI ADHWYFDLLS KLPEDLKNFR PAKKILVKLQ
   481  KFGENLDLRI RPHVLLKVLQ DLRIWELCSP DIAVAIEFVR EHIIHMPQED YISWLQSRIN
   541  IPIGPYSALR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC60 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 31 nTPM
fallopian tube: 17 nTPM
testis: 11 nTPM
cervix: 5.2 nTPM
rectum: 4.3 nTPM
urinary bladder: 3.8 nTPM

Single-cell type

ependymal cells: 474 nCPM
respiratory ciliated cells: 317 nCPM
choroid plexus epithelial cells: 297 nCPM
fallopian tube ciliated cells: 203 nCPM
early spermatids: 201 nCPM
cone photoreceptor cells: 178 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 50 nTPM
medulla oblongata: 12 nTPM
midbrain: 10 nTPM
spinal cord: 8.3 nTPM
hypothalamus: 4.4 nTPM
pons: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0
gnomAD missense Z: 0.14
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4698
Domain of unknown function (DUF4698)

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC60 as an antibody target. Whether an autoantibody or antibody against CCDC60 could matter depends on whether native CCDC60 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC60 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC60 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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