Seroatlas · Human Serome Atlas

CCDC59

Thyroid transcription factor 1-associated protein 26

Also known as: BR22, HSPC128, TAP26, TAP26_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P031
Gene: CCDC59
Ensembl: ENSG00000133773
Chromosome: 12
Canonical length: 241 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim,Plasma membrane

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

241 residues, UniProt reviewed canonical sequence.

>Q9P031|CCDC59
     1  MAPVRRSAKW RPGGIEARGE GVSTVGYRNK NVRQKTWRPN HPQAFVGSVR EGQGFAFRRK
    61  LKIQQSYKKL LRKEKKAQTS LESQFTDRYP DNLKHLYLAE EERHRKQARK VDHPLSEQVH
   121  QPLLEEQCSI DEPLFEDQCS FDQPQPEEQC IKTVNSFTIP KKNKKKTSNQ KAQEEYEQIQ
   181  AKRAAKKQEF ERRKQEREEA QRQYKKKKME VFKILNKKTK KGQPNLNVQM EYLLQKIQEK
   241  C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC59 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 38 nTPM
tongue: 18 nTPM
skeletal muscle: 15 nTPM
choroid plexus: 13 nTPM
adipose tissue: 13 nTPM
blood vessel: 12 nTPM

Single-cell type

oocytes: 332 nCPM
late primary spermatocytes: 310 nCPM
cardiomyocytes: 229 nCPM
syncytiotrophoblasts: 186 nCPM
early primary spermatocytes: 166 nCPM
epididymal principal cells: 154 nCPM

Immune cell

T-reg: 30 nTPM
basophil: 26 nTPM
naive B-cell: 24 nTPM
neutrophil: 23 nTPM
naive CD4 T-cell: 22 nTPM
MAIT T-cell: 22 nTPM

Brain region

white matter: 19 nTPM
cerebral cortex: 16 nTPM
cerebellum: 14 nTPM
medulla oblongata: 14 nTPM
basal ganglia: 13 nTPM
amygdala: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0
gnomAD missense Z: -1.37
DepMap mean gene effect: -0.61
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

Fyv7/TAP26
rRNA processing

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC59 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC59 as an antibody target. Whether an autoantibody or antibody against CCDC59 could matter depends on whether native CCDC59 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC59 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC59 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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