Seroatlas · Human Serome Atlas

CCDC57

Coiled-coil domain-containing protein 57

Also known as: CCD57_HUMAN, FLJ00130, FLJ23754

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2TAC2
Gene: CCDC57
Ensembl: ENSG00000176155
Chromosome: 17
Canonical length: 915 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules,Centriolar satellite,Cytosol

OverviewNCBI Gene

Involved in several processes, including G2/M transition of mitotic cell cycle; cilium assembly; and microtubule cytoskeleton organization. Located in centriolar satellite; centriole; and spindle microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

915 residues, UniProt reviewed canonical sequence.

>Q2TAC2|CCDC57
     1  MLPLGSEPAL NELLLRKEEE WRALQAHRTQ LQEAALQDTR SQLEEAQGKL RCLQEDFVYN
    61  LQVLEERDLE LERYDAAFAQ AREWEEARRA EVSELKIEAA KLRQALAREA RKVEELQQQQ
   121  QLAFQEHRLE LERVHSDKNG EIDHHREQYE NLKWTLERKL EELDGELALQ RQELLLEFES
   181  KMRKREHEFR LQADNMSNTA LSRELKVKLL HKELEALKEA GAKAAESLQR AEATNAELER
   241  KLQSRAGELQ DLEAMSRARV KDLEDKLHSV QLTRKKEEET FKRKHEELDR LAREKDAVLV
   301  AVKGAHVEQL QELQTRVLEL QAHCETLEAQ LRRAEWRQAD TAKEKDAAID QLREDASTVK
   361  SAWDAQIAQL SKEMVSRDLQ IQTLQEEEVK LKAQVARSQQ DIERYKQQLS LAVERERSLE
   421  RDQVQLGLDW QRRCDDIERD QIQKSEALIQ GLSMAKSQVA AKLQETEQAL QEQEVVLKAV
   481  TLERDQAVQA LRMHGLPRPG AQMLLRQHEE EISKDFPSSE IQRLREQNTS LRNAIAQMRK
   541  EMEALSHQIP PPIQTAAEST DANQPDPEAG GDAATPDYVL ALEAEIRTLK HKFKTLEKHL
   601  EDVLDPLKMS SPHAESQPSV RTSTETTGGS AQAGQAGGSV QAGQAGGSVQ AGPVSSGLAL
   661  RKLGDRVQLL NLLVTRLRQK VLREPLEPAA LQRELPREVD QVHLEVLELR KQVAELGKHL
   721  RIAQHGGAEP SGRKQPPASD AVALGREDAK SAEDEAPSRH LGKHQPRSAQ VGSRLDALQG
   781  PKTQHSIHTV TCKSPRQKED RSPKPPQAPQ HPEEHGRQSH SSSSFASGTL QDMWRLLDLG
   841  SSPSGVTSQG DSTPELPAPP AADRRPVKMQ AGIATPGMKT AAQAKAKTTG ASRSHPAKAK
   901  GCQRPPKIRN YNIMD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC57 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 16 nTPM
cerebellum: 16 nTPM
pituitary gland: 13 nTPM
prostate: 12 nTPM
testis: 11 nTPM
fallopian tube: 11 nTPM

Single-cell type

late spermatids: 1,233 nCPM
respiratory ciliated cells: 234 nCPM
epididymal principal cells: 217 nCPM
rod photoreceptor cells: 207 nCPM
early spermatids: 175 nCPM
somatotrophs: 160 nCPM

Immune cell

naive CD8 T-cell: 7.1 nTPM
naive CD4 T-cell: 3 nTPM
neutrophil: 1.1 nTPM
plasmacytoid DC: 1 nTPM
total PBMC: 0.8 nTPM
memory CD8 T-cell: 0.6 nTPM

Brain region

choroid plexus: 13 nTPM
cerebral cortex: 13 nTPM
basal ganglia: 12 nTPM
cerebellum: 11 nTPM
hippocampal formation: 9.9 nTPM
amygdala: 9.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: 0.45

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 57

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC57 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC57 as an antibody target. Whether an autoantibody or antibody against CCDC57 could matter depends on whether native CCDC57 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC57 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC57 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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