CCDC54
Coiled-coil domain-containing protein 54
Also known as: CCD54_HUMAN, FLJ25362, NYD-SP17, SP17
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NEL0
- Gene
- CCDC54
- Ensembl
- ENSG00000138483
- Chromosome
- 3
- Canonical length
- 328 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for CCDC54 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
328 residues, UniProt reviewed canonical sequence.
>Q8NEL0|CCDC54
1 MYTLHTKRVK AAARQMWTSN LSKVRQSLKN VYHKCKIRHQ DSTGYPTVTS DDCNQDDDSY
61 DGKMNLPVVL QDVKTAQVEL FSQMTDIVHM IPKVQEKTDL YQKQMEVLET RMNVNEDKQC
121 TTTKDILSMK EDIKALKKKV TELEIQNSCS TIHCLEILEG ERGKEITELL YKLIQPATLK
181 NTLASTDMEI SSAEPEKVPS YPKSTDHLEK KTISPQMKTL KKRNHQNASR SFEKAKPNIY
241 IYPDFSTWIK LTFVHGGKWT FFLSATKLEE FIQWLLSRPT ILPEEPQVIT QRYCPFTGPI
301 LSLTTICLSI FNNIYGFICS LKEEVTRLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CCDC54 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.57
- Highest tissue expression
- 116 nTPM
Expression across tissuesHPA
Tissue
- testis: 116 nTPM
- placenta: 0.9 nTPM
- heart muscle: 0.7 nTPM
- epididymis: 0.2 nTPM
- ovary: 0.2 nTPM
- prostate: 0.2 nTPM
Single-cell type
- late spermatids: 5,192 nCPM
- early spermatids: 1,586 nCPM
- late primary spermatocytes: 608 nCPM
- sertoli cells: 6.7 nCPM
- leydig cells: 4.4 nCPM
- cardiomyocytes: 4 nCPM
Immune cell
- naive B-cell: 0.2 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- white matter: 4.2 nTPM
- basal ganglia: 2.2 nTPM
- thalamus: 1.9 nTPM
- cerebral cortex: 1.8 nTPM
- hippocampal formation: 1.5 nTPM
- medulla oblongata: 1.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.91
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.17
- DepMap mean gene effect
- 0.09
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Coiled-coil domain-containing protein 54
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CCDC54 as an antibody target. Whether an autoantibody or antibody against CCDC54 could matter depends on whether native CCDC54 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CCDC54 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CCDC54 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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