Seroatlas · Human Serome Atlas

CCDC43

Coiled-coil domain-containing protein 43

Also known as: CCD43_HUMAN, FLJ31795

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MW1
Gene: CCDC43
Ensembl: ENSG00000180329
Chromosome: 17
Canonical length: 224 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

224 residues, UniProt reviewed canonical sequence.

>Q96MW1|CCDC43
     1  MAAPSEVAAI APGEGDGGGG GFGSWLDGRL EALGVDRAVY GAYILGILQE EEEEEKLDAL
    61  QGILSAFLEE DSLLNICKEI VERWSETQNV VTKVKKEDEV QAIATLIEKQ AQIVVKPRMV
   121  SEEEKQRKAA LLAQYADVTD EEDEADEKDD SGATTMNIGS DKLLFRNTNV EDVLNARKLE
   181  RDSLRDESQR KKEQDKLQRE RDKLAKQERK EKEKKRTQRG ERKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC43 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 69 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 69 nTPM
tongue: 40 nTPM
bone marrow: 20 nTPM
heart muscle: 19 nTPM
retina: 17 nTPM
parathyroid gland: 14 nTPM

Single-cell type

oocytes: 60 nCPM
migrating cytotrophoblasts: 60 nCPM
extravillous trophoblasts: 58 nCPM
megakaryocytes: 50 nCPM
cytotrophoblasts: 48 nCPM
esophageal suprabasal cells: 45 nCPM

Immune cell

intermediate monocyte: 18 nTPM
myeloid DC: 18 nTPM
NK-cell: 17 nTPM
classical monocyte: 16 nTPM
T-reg: 15 nTPM
memory CD8 T-cell: 14 nTPM

Brain region

cerebral cortex: 22 nTPM
cerebellum: 21 nTPM
white matter: 21 nTPM
thalamus: 19 nTPM
hypothalamus: 19 nTPM
pons: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 0.3
DepMap mean gene effect: -0.31
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 43
CCDC43, PWI-like domain
CCDC43 PWI-like domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC43 as an antibody target. Whether an autoantibody or antibody against CCDC43 could matter depends on whether native CCDC43 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC43 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC43 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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