Seroatlas · Human Serome Atlas

CCDC34

Coiled-coil domain-containing protein 34

Also known as: CCD34_HUMAN, L15, NY-REN-41, RAMA3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96HJ3
Gene
CCDC34
Ensembl
ENSG00000109881
Chromosome
11
Canonical length
373 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nuclear membrane,Nucleoli fibrillar center,Calyx,Connecting piece,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Involved in spermatogenesis. Located in sperm midpiece. Implicated in spermatogenic failure 76. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

373 residues, UniProt reviewed canonical sequence.

>Q96HJ3|CCDC34
     1  MWAAGRWGPT FPSSYAGFSA DCRPRSRPSS DSCSVPMTGA RGQGLEVVRS PSPPLPLSCS
    61  NSTRSLLSPL GHQSFQFDED DGDGEDEEDV DDEEDVDEDA HDSEAKVASL RGMELQGCAS
   121  TQVESENNQE EQKQVRLPES RLTPWEVWFI GKEKEERDRL QLKALEELNQ QLEKRKEMEE
   181  REKRKIIAEE KHKEWVQKKN EQKRKEREQK INKEMEEKAA KELEKEYLQE KAKEKYQEWL
   241  KKKNAEECER KKKEKEKEKQ QQAEIQEKKE IAEKKFQEWL ENAKHKPRPA AKSYGYANGK
   301  LTGFYSGNSY PEPAFYNPIP WKPIHMPPPK EAKDLSGRKS KRPVISQPHK SSSLVIHKAR
   361  SNLCLGTLCR IQR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • testis: 48 nTPM
  • choroid plexus: 21 nTPM
  • basal ganglia: 15 nTPM
  • thymus: 15 nTPM
  • cerebral cortex: 14 nTPM
  • bone marrow: 13 nTPM

Single-cell type

  • late primary spermatocytes: 607 nCPM
  • early spermatids: 324 nCPM
  • differentiating spermatogonia: 272 nCPM
  • early primary spermatocytes: 212 nCPM
  • epididymal efferent duct ciliated cells: 169 nCPM
  • undifferentiated spermatogonia: 156 nCPM

Immune cell

  • T-reg: 6.7 nTPM
  • naive CD4 T-cell: 4.5 nTPM
  • memory CD8 T-cell: 4.2 nTPM
  • naive B-cell: 4 nTPM
  • memory CD4 T-cell: 3.9 nTPM
  • NK-cell: 3.8 nTPM

Brain region

  • choroid plexus: 12 nTPM
  • cerebral cortex: 11 nTPM
  • amygdala: 9.9 nTPM
  • hippocampal formation: 9.5 nTPM
  • hypothalamus: 9.5 nTPM
  • basal ganglia: 9.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCDC34.

Disease | AllUniProt

Conditions CCDC34 is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 52 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Spermatogenic failure 76

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.02
gnomAD pLI
0
gnomAD missense Z
-0.26
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Coiled-coil domain-containing protein 34/181
  • Coiled-coil domain-containing protein 34
  • Coiled-coil domain-containing protein 34

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC34 as an antibody target. Whether an autoantibody or antibody against CCDC34 could matter depends on whether native CCDC34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC34 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC34. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...