Seroatlas · Human Serome Atlas

CCDC32

Coiled-coil domain-containing protein 32

Also known as: C15orf57, CCD32_HUMAN, MGC20481

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BV29
Gene
CCDC32
Ensembl
ENSG00000128891
Chromosome
15
Canonical length
185 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nuclear speckles,Vesicles

OverviewNCBI Gene

Involved in head development and regulation of clathrin-dependent endocytosis. Part of clathrin-coated pit. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

185 residues, UniProt reviewed canonical sequence.

>Q9BV29|CCDC32
     1  MKMFESADST ATRSGQDLWA EICSCLPNPE QEDGANNAFS DSFVDSCPEG EGQREVADFA
    61  VQPAVKPWAP LQDSEVYLAS LEKKLRRIKG LNQEVTSKDM LRTLAQAKKE CWDRFLQEKL
   121  ASEFFVDGLD SDESTLEHFK RWLQPDKVAV STEEVQYLIP PESQVEKPVA EDEPAAGDKP
   181  AAAEQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC32 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 27 nTPM
  • choroid plexus: 25 nTPM
  • tonsil: 24 nTPM
  • ovary: 22 nTPM
  • kidney: 21 nTPM
  • spleen: 20 nTPM

Single-cell type

  • hofbauer cells: 135 nCPM
  • cytotrophoblasts: 131 nCPM
  • plasma cells: 129 nCPM
  • syncytiotrophoblasts: 117 nCPM
  • b-cells: 99 nCPM
  • migrating cytotrophoblasts: 83 nCPM

Immune cell

  • naive B-cell: 168 nTPM
  • memory B-cell: 148 nTPM
  • basophil: 58 nTPM
  • plasmacytoid DC: 58 nTPM
  • T-reg: 51 nTPM
  • myeloid DC: 43 nTPM

Brain region

  • pons: 29 nTPM
  • hypothalamus: 28 nTPM
  • hippocampal formation: 28 nTPM
  • midbrain: 27 nTPM
  • choroid plexus: 25 nTPM
  • cerebral cortex: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCDC32.

Disease | AllUniProt

Conditions CCDC32 is implicated in, by any mechanism.

  • Cardiofacioneurodevelopmental syndrome (CFNDS) MIM:619123

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 18 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Cardiofacioneurodevelopmental syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0.39
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Coiled-coil domain containing protein 32
  • Coiled-coil domain containing 32

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC32 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC32 as an antibody target. Whether an autoantibody or antibody against CCDC32 could matter depends on whether native CCDC32 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC32 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC32 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC32. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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