Seroatlas · Human Serome Atlas

CCDC30

Coiled-coil domain-containing protein 30

Also known as: CCD30_HUMAN, FLJ20972, LOC728621, PFD6L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VVM6
Gene: CCDC30
Ensembl: ENSG00000186409
Chromosome: 1
Canonical length: 783 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CCDC30 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

783 residues, UniProt reviewed canonical sequence.

>Q5VVM6|CCDC30
     1  MSQEKNEMFE SEWSKERERE KQLASGLDTA EKALKVESEE LQKSKSELIC LYNEVHNLPG
    61  ESESKDHFLI ACDLLQRENS ELETKVLKLS QEFAQLNHFT LGGKTAPSNL ITSENTCKDP
   121  ESNEPILETE IQSRKEETEE LCPKLGERKQ KEIPEESVKE GSFPREGQKE EGSQQNRDMK
   181  DEEKEQQLTM KPEEIVRLRE ELSHINQSLL QSQSSGDSSD DSGAQHPSSG EKLKYNQQGE
   241  VQQLHQNLHR LQILCNSAEN ELRYERGQNL DLKQHNSLLQ EENIKIKIEL KHAQQKLLDS
   301  TKMCSSLTAE YKHCQQKIKE LELEVLKHTQ SIKSQNNLQE KLVQEKSKVA DAEEKILDLQ
   361  RKLEHAHKVC LTDTCISEKQ QLEEKIKEAT QNEAKVKQQY QEEQQKRKLL YQNVDELHRQ
   421  VRTLQDKENL LEMTCSQQQS RIQQQEALLK QLENEKRKYD EHVKSNQELS EKLSKLQQEK
   481  EALREEYLRL LKLLNVHVRN YNEKHHQQKV KLQKVKYRLT NEVELRDKRI NQFEDEIGIL
   541  QHKIEKEKAI QDQITAQNDT LLLEKRKLQE QVIEQEQLIH SNKWTISSIQ SRVLYMDKEN
   601  KQLQENSLRL TQQIGFLERI IRSIHIRRGE NLKEFPVPKW WHRGKLASLP PTKKQKEIYS
   661  TEVFTSNNAE LQHEDESVPE ATEKWKHSEQ METTISDILE SEVVNEILPL SNSSFSGKGL
   721  VESFASLQET EEIKSKEAMA SSKSPEKSPE NLVCSQNSEA GYINVASLKE THGIQEQDQK
   781  SEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 9.6 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 9.6 nTPM
pituitary gland: 6.5 nTPM
fallopian tube: 5.4 nTPM
thyroid gland: 4.8 nTPM
epididymis: 4.6 nTPM
kidney: 4.3 nTPM

Single-cell type

ependymal cells: 1,267 nCPM
choroid plexus epithelial cells: 774 nCPM
respiratory ciliated cells: 702 nCPM
fallopian tube ciliated cells: 341 nCPM
endometrial ciliated cells: 315 nCPM
lactotrophs: 301 nCPM

Immune cell

basophil: 5.8 nTPM
neutrophil: 5.2 nTPM
eosinophil: 2.5 nTPM
non-classical monocyte: 1.7 nTPM
plasmacytoid DC: 1.7 nTPM
naive B-cell: 1.4 nTPM

Brain region

choroid plexus: 44 nTPM
medulla oblongata: 30 nTPM
midbrain: 27 nTPM
hypothalamus: 27 nTPM
cerebellum: 25 nTPM
basal ganglia: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
gnomAD missense Z: 0.91
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4686
Coiled-coil domain-containing protein Prefoldin subunit beta-like
Domain of unknown function (DUF4686)

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC30 as an antibody target. Whether an autoantibody or antibody against CCDC30 could matter depends on whether native CCDC30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC30 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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