Seroatlas · Human Serome Atlas

CCDC3

Coiled-coil domain-containing protein 3

Also known as: CCDC3_HUMAN, DKFZp761F241

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQI4
Gene: CCDC3
Ensembl: ENSG00000151468
Chromosome: 10
Canonical length: 270 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Nucleoplasm,Cytosol
Secretome location: Secreted to blood
Quaternary structure: Homodimer

OverviewNCBI Gene

Involved in negative regulation of lipid metabolic process; negative regulation of tumor necrosis factor-mediated signaling pathway; and signal transduction. Located in endoplasmic reticulum and extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

270 residues, UniProt reviewed canonical sequence.

>Q9BQI4|CCDC3
     1  MLRQLLLAAL CLAGPPAPAR ACQLPSEWRP LSEGCRAELA ETIVYARVLA LHPEAPGLYN
    61  HLPWQYHAGQ GGLFYSAEVE MLCDQAWGSM LEVPAGSRLN LTGLGYFSCH SHTVVQDYSY
   121  FFFLRMDENY NLLPHGVNFQ DAIFPDTQEN RRMFSSLFQF SNCSQGQQLA TFSSDWEIQE
   181  DSRLMCSSVQ KALFEEEDHV KKLQQKVATL EKRNRQLRER VKKVKRSLRQ ARKKGRHLEL
   241  ANQKLSEKLA AGALPHINAR GPVRPPYLRG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 310 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 310 nTPM
skin: 125 nTPM
adipose tissue: 86 nTPM
ovary: 79 nTPM
gallbladder: 66 nTPM
fallopian tube: 63 nTPM

Single-cell type

medullary thymic epithelial cells: 367 nCPM
vascular smooth muscle cells: 331 nCPM
adipocytes: 282 nCPM
pericytes: 135 nCPM
brain excitatory neurons: 109 nCPM
oocytes: 106 nCPM

Immune cell

gdT-cell: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 52 nTPM
hippocampal formation: 43 nTPM
amygdala: 37 nTPM
basal ganglia: 36 nTPM
white matter: 34 nTPM
hypothalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: -0.85
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 3

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC3 as an antibody target. Whether an autoantibody or antibody against CCDC3 could matter depends on whether native CCDC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC3 is annotated as secreted, so native CCDC3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCDC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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