Seroatlas · Human Serome Atlas

CCDC28A

Coiled-coil domain-containing protein 28A

Also known as: CC28A_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IWP9
Gene
CCDC28A
Canonical length
274 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CCDC28A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

274 residues, UniProt reviewed canonical sequence.

>Q8IWP9|CCDC28A
     1  MPRAEPRATL GEQEKAGLPL GAWRLYLLRH FRKQTELRRS GSRDVTGALL VAAAVASEAV
    61  GSLRVAEGGP NTLLLQVLRS WPWCNKELKT MEERKVKRRS PKSFSAHCTQ VVNAKKNAIP
   121  VSKSTGFSNP ASQSTSQRPK LKRVMKEKTK PQGGEGKGAQ STPIQHSFLT DVSDVQEMER
   181  GLLSLLNDFH SGKLQAFGNE CSIEQMEHVR GMQEKLARLN LELYGELEEL PEDKRKTASD
   241  SNLDRLLSDL EELNSSIQKL HLADAQDVPN TSAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC28A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
81 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 81 nTPM
  • liver: 63 nTPM
  • kidney: 56 nTPM
  • thyroid gland: 51 nTPM
  • parathyroid gland: 50 nTPM
  • salivary gland: 49 nTPM

Single-cell type

  • early spermatids: 186 nCPM
  • syncytiotrophoblasts: 139 nCPM
  • late spermatids: 127 nCPM
  • cardiomyocytes: 127 nCPM
  • fallopian tube ciliated cells: 111 nCPM
  • neutrophils: 107 nCPM

Immune cell

  • neutrophil: 251 nTPM
  • T-reg: 160 nTPM
  • basophil: 139 nTPM
  • eosinophil: 121 nTPM
  • NK-cell: 116 nTPM
  • memory B-cell: 108 nTPM

Brain region

  • choroid plexus: 40 nTPM
  • hippocampal formation: 32 nTPM
  • hypothalamus: 31 nTPM
  • basal ganglia: 29 nTPM
  • cerebral cortex: 28 nTPM
  • pons: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.65
gnomAD pLI
0
gnomAD missense Z
-0.1
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC28A as an antibody target. Whether an autoantibody or antibody against CCDC28A could matter depends on whether native CCDC28A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC28A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC28A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC28A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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