Seroatlas · Human Serome Atlas

CCDC27

Coiled-coil domain-containing protein 27

Also known as: CCD27_HUMAN, FLJ32825

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2M243
Gene: CCDC27
Ensembl: ENSG00000162592
Chromosome: 1
Canonical length: 656 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for CCDC27 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

656 residues, UniProt reviewed canonical sequence.

>Q2M243|CCDC27
     1  MFEAIFPSTP QARLKRDPRE KPGLSSFRST FRQQSSLGLC IPRLMLPKEA SPSQRHSSMS
    61  SSMARALVLL QSMASRDARC PEWKPHQKPR TLSKSVQTIS RYYRKTSEPK DAASLTGFMS
   121  KMELRRVFPT HPDCPQFSTR ATSMSHCGSP TEADLSGEID NSSETWRGTQ DLFLARRGSD
   181  TNVDGYLLPF SKSICEFDYL RKRRKSQTLS PVTSSSVASQ SCLRKRMPWY LSVIHEKDHC
   241  LSELEIQVQK KDEEILLLQE EREALKMQLK CLLKGKGQET SMSPGRREQL SDASLKLGRL
   301  SLLKAFSRHE EELQHWWQMQ EESAAPERGK EPDLGGGEED EGLEGEPDGV EDTGAWGGVS
   361  QMGSVHEEGS EEEEEEEGDR DEDSEERELP EEEEIPRRRA SSLAESFEEE LLAQLEEYEQ
   421  VILDFQFNLE ATRTRYSLAT GVIASLQQQV DFQETQLRKI NTENETLQKE LRERRQQLQA
   481  MTDKFSNLRE DKKHQEMMGL IEKDNQLLRQ QVSELERKLT KRDCVISELD TKVSQLQEQV
   541  ELDQNHLQRW KQLQEDLQSK KEMIQQAEQH TRVALESSQS RLERLRNKII QATFSISGTK
   601  SLANEISDND ILEALQRIIS ERSDYYNQLK QKGVKVPPLQ QSEAFLTSKS KKGTSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

testis: 16 nTPM
ovary: 0.3 nTPM
heart muscle: 0.2 nTPM
endometrium: 0.1 nTPM
salivary gland: 0.1 nTPM
thyroid gland: 0.1 nTPM

Single-cell type

early spermatids: 343 nCPM
late primary spermatocytes: 115 nCPM
oocytes: 92 nCPM
late spermatids: 55 nCPM
cardiomyocytes: 27 nCPM
epicardial cells: 6.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 0.7 nTPM
medulla oblongata: 0.6 nTPM
amygdala: 0.4 nTPM
spinal cord: 0.4 nTPM
white matter: 0.4 nTPM
basal ganglia: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: -0.06
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Coiled-coil and Forkhead-associated domain-containing protein

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC27 as an antibody target. Whether an autoantibody or antibody against CCDC27 could matter depends on whether native CCDC27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC27 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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