Seroatlas · Human Serome Atlas

CCDC24

Coiled-coil domain-containing protein 24

Also known as: CCD24_HUMAN, MGC45441

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N4L8
Gene: CCDC24
Ensembl: ENSG00000159214
Chromosome: 1
Canonical length: 307 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to act upstream of or within blastocyst hatching. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>Q8N4L8|CCDC24
     1  MLRHSPSLWE LVEEHVPLRE RREVKRILGE AAVDLSLELR AEVAMLRALL QEARSSQAPS
    61  SRPISDPSSL LAPPPLLKDL LRQELRQLLQ GLRHKAICEG RDQAQAWVQY SPRVLHFALE
   121  EPRCDLPEQE IFQMRGGGPS SGHRDLSIIK DQLNVSNIDQ VARHLRGLLE EECHTLEREI
   181  LILQRCLEEE YLRPCHPSEA ALEPTLAELK EQKKAMEQEL QASVGPSCVS PNHRQRPLGS
   241  STQGLRPPLP LCGVAPLQCC LPAPPLEPYL RPRGQSATHR WGRQLQCSPR EGPASTPMSS
   301  AAPQAPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

testis: 18 nTPM
kidney: 12 nTPM
pituitary gland: 12 nTPM
choroid plexus: 12 nTPM
fallopian tube: 11 nTPM
amygdala: 10 nTPM

Single-cell type

respiratory ciliated cells: 97 nCPM
fallopian tube ciliated cells: 84 nCPM
late primary spermatocytes: 79 nCPM
epididymal efferent duct ciliated cells: 60 nCPM
ependymal cells: 57 nCPM
differentiating spermatogonia: 56 nCPM

Immune cell

memory B-cell: 3.5 nTPM
naive B-cell: 2.3 nTPM
intermediate monocyte: 2.2 nTPM
non-classical monocyte: 1.8 nTPM
eosinophil: 1 nTPM
classical monocyte: 0.4 nTPM

Brain region

choroid plexus: 5.2 nTPM
thalamus: 4.7 nTPM
hypothalamus: 4.2 nTPM
basal ganglia: 3.9 nTPM
cerebral cortex: 3.8 nTPM
midbrain: 3.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.46
gnomAD pLI: 0
gnomAD missense Z: -0.68
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

blastocyst hatching

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 24
Coiled-coil domain-containing protein 24 family

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC24 as an antibody target. Whether an autoantibody or antibody against CCDC24 could matter depends on whether native CCDC24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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