Seroatlas · Human Serome Atlas

CCDC200

Coiled-coil domain-containing protein 200

Also known as: CC200_HUMAN, LINC00854, TMEM106A-AS1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GVQ3
Gene
CCDC200
Ensembl
ENSG00000236383
Chromosome
17
Canonical length
168 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CCDC200 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

168 residues, UniProt reviewed canonical sequence.

>A0A1B0GVQ3|CCDC200
     1  MGSAYHWEAR RRQMALDRRR WLMAQQQQEL QQKEQELKNH QEEEQQSEEK LQPHKKLNVP
    61  QPPVAKLWTS QEQPQPSQQQ PSVQPPSQPP PQPSTLPQAQ VWPGPQPPQP QPPPQPTQPS
   121  AQARCTQHTS KCNLQDSQRP GLMNPCQSSP IRNTGYSQLK STNYIQQW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC200 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • testis: 42 nTPM
  • retina: 4.2 nTPM
  • kidney: 3.6 nTPM
  • spleen: 2.5 nTPM
  • appendix: 2.3 nTPM
  • skin: 2.3 nTPM

Single-cell type

  • late spermatids: 3,421 nCPM
  • early spermatids: 458 nCPM
  • mucous neck cells: 222 nCPM
  • monocyte progenitors: 183 nCPM
  • gastric chief cells: 181 nCPM
  • mast cells: 165 nCPM

Immune cell

  • basophil: 8.3 nTPM
  • NK-cell: 7.2 nTPM
  • neutrophil: 2.9 nTPM
  • naive B-cell: 1.7 nTPM
  • plasmacytoid DC: 1.6 nTPM
  • eosinophil: 1.1 nTPM

Brain region

  • cerebellum: 33 nTPM
  • white matter: 21 nTPM
  • cerebral cortex: 20 nTPM
  • medulla oblongata: 18 nTPM
  • hypothalamus: 17 nTPM
  • midbrain: 16 nTPM

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC200 as an antibody target. Whether an autoantibody or antibody against CCDC200 could matter depends on whether native CCDC200 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC200 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC200 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC200. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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