Seroatlas · Human Serome Atlas

CCDC198

Factor associated with metabolism and energy

Also known as: C14orf105, FAME_HUMAN, FLJ10650

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NVL8
Gene: CCDC198
Ensembl: ENSG00000100557
Chromosome: 14
Canonical length: 296 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be involved in energy homeostasis. Predicted to be part of cytoplasmic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

296 residues, UniProt reviewed canonical sequence.

>Q9NVL8|CCDC198
     1  MGLSHSKTHL RVIKVAPLQN KEVETPSAGR VDFAFNQNLE EKTSYSLARL QDQNKALEGQ
    61  LPPLQENWYG RYSTASRDMY FDIPLEHRET SIIKRHPPQR LQKLEPIDLP RVITSGRLLS
   121  QREARTMHKA KQVLEKKMQT PMYTSENRQY LHKMQVLEMI RKRQEAQMEL KKSLHGEARI
   181  NKQSPRDHKA KKTLQSTPRN DDHDLLTMLP DEILNRGPGN SKNTEFLKHQ AVNNYCPWKI
   241  GKMETWLHEQ EAQGQLLWDS SSSDSDEQGK DEKKPRALVR TRTERIPLFD EFFDQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC198 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

kidney: 86 nTPM
liver: 36 nTPM
pancreas: 32 nTPM
fallopian tube: 26 nTPM
gallbladder: 16 nTPM
epididymis: 1.7 nTPM

Single-cell type

proximal tubule cells: 451 nCPM
epididymal efferent duct ciliated cells: 363 nCPM
renal connecting tubule cells: 319 nCPM
distal convoluted tubule cells: 237 nCPM
loop of henle epithelial cells: 230 nCPM
renal collecting duct principal cells: 195 nCPM

Immune cell

T-reg: 2.2 nTPM
naive CD8 T-cell: 1.8 nTPM
total PBMC: 1.8 nTPM
basophil: 1.6 nTPM
memory CD4 T-cell: 1.4 nTPM
naive CD4 T-cell: 1.2 nTPM

Brain region

white matter: 6.2 nTPM
pons: 5.2 nTPM
cerebellum: 5.1 nTPM
medulla oblongata: 5 nTPM
hypothalamus: 4.9 nTPM
basal ganglia: 4.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

energy homeostasis

Cellular components

Protein domainsUniProt · Pfam · InterPro

Factor associated with metabolism and energy
Domain of unknown function (DUF4619)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC198 as an antibody target. Whether an autoantibody or antibody against CCDC198 could matter depends on whether native CCDC198 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC198 is annotated at the cell surface, where native CCDC198 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CCDC198 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...