Seroatlas · Human Serome Atlas

CCDC197

Uncharacterized protein CCDC197

Also known as: CC197_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NCU1
Gene
CCDC197
Canonical length
143 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CCDC197 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

143 residues, UniProt reviewed canonical sequence.

>Q8NCU1|CCDC197
     1  MAAMDTGQRA DPSNPGDKEG DLQGLWQELY QLQAKQKKLK REVEKHKLFE DYLIKVLEKI
    61  PEGCTGWEEP EEVLVEATVK HYGKLFTASQ DTQKRLEAFC QMIQAVHRSL ESLEEDHRAL
   121  IASRSGCVSC RRSATASRSS GGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC197 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
7.8 nTPM

Expression across tissuesHPA

Tissue

  • testis: 7.8 nTPM
  • skeletal muscle: 1 nTPM
  • tongue: 0.6 nTPM
  • heart muscle: 0.5 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • late spermatids: 569 nCPM
  • early spermatids: 113 nCPM
  • late primary spermatocytes: 34 nCPM
  • peritubular myoid cells: 2.7 nCPM
  • sertoli cells: 1.4 nCPM
  • leydig cells: 1.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 1.4 nTPM
  • basal ganglia: 1.2 nTPM
  • medulla oblongata: 0.9 nTPM
  • white matter: 0.6 nTPM
  • cerebral cortex: 0.5 nTPM
  • thalamus: 0.4 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC197 as an antibody target. Whether an autoantibody or antibody against CCDC197 could matter depends on whether native CCDC197 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC197 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC197 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC197. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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