Seroatlas · Human Serome Atlas

CCDC196

Coiled-coil domain-containing protein 196

Also known as: C14orf53, CC196_HUMAN, LINC00238, NCRNA00238

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GTZ2
Gene
CCDC196
Ensembl
ENSG00000196553
Chromosome
14
Canonical length
297 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CCDC196 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

297 residues, UniProt reviewed canonical sequence.

>A0A1B0GTZ2|CCDC196
     1  MTSGANSSGS YLPSEIRSSK IDDNYLKELN EDLKLRKQEL LEMLKPLEDK NNLLFQKLMS
    61  NLEEKQRSLQ IMRQIMAGKG CEESSVMELL KEAEEMKQNL ERKNKMLRKE MEMLWNKTFE
   121  AEELSDQQKA PQTKNKADLQ DGKAPKSPSS PRKTESELEK SFAEKVKEIR KEKQQRKMEW
   181  VKYQEQNNIL QNDFHGKVIE LRIEALKNYQ KANDLKLSLY LQQNFEPMQA FLNLPGSQGT
   241  MGITTMDRVT TGRNEHHVRI LGTKIYTEQQ GTKGSQLDNT GGRLFFLRSL PDEALKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC196 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
3.7 nTPM

Expression across tissuesHPA

Tissue

  • testis: 3.7 nTPM
  • basal ganglia: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • late spermatids: 5,553 nCPM
  • early spermatids: 1,450 nCPM
  • late primary spermatocytes: 225 nCPM
  • epicardial cells: 121 nCPM
  • adipocytes: 62 nCPM
  • epididymal clear cells: 61 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 1.1 nTPM
  • hypothalamus: 0.6 nTPM
  • white matter: 0.5 nTPM
  • basal ganglia: 0.4 nTPM
  • medulla oblongata: 0.4 nTPM
  • pons: 0.4 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Coiled-coil domain-containing protein 196

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC196 as an antibody target. Whether an autoantibody or antibody against CCDC196 could matter depends on whether native CCDC196 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC196 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC196 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC196. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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