Seroatlas · Human Serome Atlas

CCDC195

Coiled-coil domain-containing protein 195

Also known as: CC195_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GUA6
Gene
CCDC195
Ensembl
ENSG00000283428
Chromosome
2
Canonical length
201 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CCDC195 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>A0A1B0GUA6|CCDC195
     1  MEADIQLMRL IQEMRAEIHK LEKENQALRM KLTASSQRAS GSGRESGDER EEEAPGQSPA
    61  TLQGAVSTDA APAVQEHQGN VMIVRRYSIS SSVCSSAVND PWKSGKSHPK SGILEGQRTL
   121  KSLACSPIKK QDMEEKVFAT DSLTSNRTSQ RASPEHVCGC RDKTKAVSFL LPMDMSSYSK
   181  NSSSLKHSPN QATNQLSIIA E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC195 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
0.8 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 0.8 nTPM
  • pituitary gland: 0.2 nTPM
  • skeletal muscle: 0.2 nTPM
  • tonsil: 0.2 nTPM
  • kidney: 0.1 nTPM
  • lymph node: 0.1 nTPM

Single-cell type

  • undifferentiated spermatogonia: 3.1 nCPM
  • gonadotrophs: 3 nCPM
  • myosatellite cells: 2.6 nCPM
  • enteric transient amplifying cells: 1.8 nCPM
  • early primary spermatocytes: 1.7 nCPM
  • colonocytes: 1.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 0.2 nTPM
  • cerebral cortex: 0.2 nTPM
  • hypothalamus: 0.2 nTPM
  • medulla oblongata: 0.2 nTPM
  • pons: 0.2 nTPM
  • thalamus: 0.2 nTPM

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC195 as an antibody target. Whether an autoantibody or antibody against CCDC195 could matter depends on whether native CCDC195 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC195 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC195 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC195. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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