Seroatlas · Human Serome Atlas

CCDC194

Coiled-coil domain-containing protein 194

Also known as: CC194_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GVG4
Gene
CCDC194
Ensembl
ENSG00000269720
Chromosome
19
Canonical length
234 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CCDC194 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

234 residues, UniProt reviewed canonical sequence.

>A0A1B0GVG4|CCDC194
     1  MAEPGPEPGR AWRVLALCGV AVFLAAAAAG GALVAWNLAA SAARGPRCPE PGANATAPPG
    61  DPPPGVDDLR RRLAEAAERE EALARQLDQA ESIRHELEKA LKACEGRQSR LQTQLTTLKI
   121  EMDEAKAQGT QMGAENGALT EALARWEAAA TESTRRLDEA LRRAGVAEAE GEACAAREAA
   181  LRERLNVLEA EMSPQRRVPR PRPRSGSRPR PSPRSRSRSG PSGGCRRPAR RARG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC194 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
2.1 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 2.1 nTPM
  • skeletal muscle: 1.1 nTPM
  • placenta: 0.8 nTPM
  • bone marrow: 0.5 nTPM
  • spleen: 0.5 nTPM
  • lymph node: 0.4 nTPM

Single-cell type

  • thymic myoid cells: 30 nCPM
  • ovarian stromal cells: 24 nCPM
  • late primary spermatocytes: 13 nCPM
  • medullary thymic epithelial cells: 12 nCPM
  • adrenal medulla cells: 11 nCPM
  • granulosa cells: 11 nCPM

Immune cell

  • basophil: 2 nTPM
  • neutrophil: 1.1 nTPM
  • naive B-cell: 0.5 nTPM
  • NK-cell: 0.5 nTPM
  • plasmacytoid DC: 0.5 nTPM
  • memory B-cell: 0.4 nTPM

Brain region

  • cerebral cortex: 7.8 nTPM
  • white matter: 7 nTPM
  • cerebellum: 5.9 nTPM
  • amygdala: 5.6 nTPM
  • basal ganglia: 5.6 nTPM
  • medulla oblongata: 5.4 nTPM

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC194 as an antibody target. Whether an autoantibody or antibody against CCDC194 could matter depends on whether native CCDC194 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC194 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC194 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC194. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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