Seroatlas · Human Serome Atlas

CCDC192

Coiled-coil domain-containing protein 192

Also known as: CC192_HUMAN, LINC01183

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DO97
Gene
CCDC192
Ensembl
ENSG00000230561
Chromosome
5
Canonical length
292 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CCDC192 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

292 residues, UniProt reviewed canonical sequence.

>P0DO97|CCDC192
     1  MMPVDVCPRD RGSQWVWLEM GQCYSKKSVV PESDTSERSS MTSGSSESDI PQENKVSKAS
    61  LDTGQMAFTL AQLESLEICL KEAEEKAKAL SEQLSVSEGT KSKLLEQVSR LEEKLEAVDH
   121  KEASGGPYEK MVLVKDQCIQ KLQAEVKASQ EQLIAQKLKH EKKVKKLQTD LATANAITVL
   181  ELNEKIKTLY EGKPAPREDS LLEGFCGGLP PVEEGDRKIS LIMELSTQVS LQTERITQLK
   241  EVLEEKERKI QQLEAERSPH PPQEVKDPPG CLPEAPVFST HDIPPVVSDE NL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC192 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • testis: 14 nTPM
  • skeletal muscle: 3.1 nTPM
  • adipose tissue: 1.1 nTPM
  • ovary: 1 nTPM
  • cervix: 0.8 nTPM
  • tongue: 0.7 nTPM

Single-cell type

  • early spermatids: 311 nCPM
  • late primary spermatocytes: 260 nCPM
  • late spermatids: 140 nCPM
  • cardiomyocytes: 94 nCPM
  • leydig cells: 85 nCPM
  • epicardial cells: 52 nCPM

Immune cell

  • MAIT T-cell: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 1.1 nTPM
  • basal ganglia: 0.8 nTPM
  • amygdala: 0.7 nTPM
  • hippocampal formation: 0.7 nTPM
  • thalamus: 0.7 nTPM
  • hypothalamus: 0.6 nTPM

Protein domainsUniProt · Pfam · InterPro

  • Coiled-coil domain-containing protein 192

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC192 as an antibody target. Whether an autoantibody or antibody against CCDC192 could matter depends on whether native CCDC192 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC192 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC192 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC192. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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