Seroatlas · Human Serome Atlas

CCDC191

Coiled-coil domain-containing protein 191

Also known as: CC191_HUMAN, KIAA1407

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NCU4
Gene: CCDC191
Ensembl: ENSG00000163617
Chromosome: 3
Canonical length: 936 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

No narrative summary is available for CCDC191 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

936 residues, UniProt reviewed canonical sequence.

>Q8NCU4|CCDC191
     1  MLLAPQGRSF SKKRMGLNRW KRFTRKPSPK PTFGPDSVEH WIKRVEKASE FAVSNAFFTR
    61  NSDLPRSPWG QITDLKTSEQ IEDHDEIYAE AQELVNDWLD TKLKQELASE EEGDAKNTVS
   121  SVTIMPEANG HLKYDKFDDL CGYLEEEEES TTVQKFIDHL LHKNVVDSAM MEDLGRKENQ
   181  DKKQQKDPRL TMEMRHKQVK ENRLRREKEL EYQRIEKTLK KSAFLEAQCL VQEEKKRKAL
   241  EAKKEEEEIQ REMVKLRREI IERRRTVKAA WKIEKKRQEE NSQNSSEKVM FQSTHILPDE
   301  EKMVKERKRK LKEVLIQTFK ENQQCQKRYF AAWHKLILDH RIKLGKAGTL SDWKIQLKVL
   361  RAWRDYTRFQ KLERETQALE NDLREENRKQ QLATEYNRKQ VLRHCFTEWQ HWHGAELLKR
   421  ELALTKEETR KKMDALLQAA SLGKLSANGL SGISLPEEAT AMVGPPVKNG QETAVPPLWE
   481  KPPLGSSGCM LSPPLGRTTT GNLQGSLQNV SLSAPGNKQH KTLGAEPSQQ PGSNETLRTT
   541  SQKAEPLCLG HFHNRHVFQQ QLIEKQKKKL QEQQKTILEL KKNLQLAEAQ WAAEHALAVT
   601  EAQSHLLSKP REEEPRTCQM LVNSPVASPG TEGRSDSRNS LSGLRRKPKQ LMTPHPILKA
   661  MEERAIQRAE CRRILAEKKK KQEEEKLAQL KAQEEERQKR EAEEKEAQLE RKREEKRLKK
   721  MKELEKQKRI KRNQQLEAIA KEHYERVLLR KKGLEPWKRL RMQSKQNIQV AEEHYSLFLQ
   781  RKYMLTWFQR SQESLARKMA QADQFYSQIL LKRVIQSWLQ YVIDLQEEVR KFCVHFLQKK
   841  IFRAWFNMVR EVKIDSQGKH EIAAEHSDRR ILWITLRTWK KFVKFMKEER VKEERRQQLR
   901  RKVVEILPDF QVPGRYHELY QQSDTWSLSK TSLVNE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC191 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 14 nTPM
retina: 13 nTPM
fallopian tube: 11 nTPM
pituitary gland: 11 nTPM
testis: 9.5 nTPM
thyroid gland: 8.1 nTPM

Single-cell type

ependymal cells: 269 nCPM
respiratory ciliated cells: 264 nCPM
fallopian tube ciliated cells: 223 nCPM
choroid plexus epithelial cells: 173 nCPM
endometrial ciliated cells: 135 nCPM
somatotrophs: 122 nCPM

Immune cell

memory B-cell: 9 nTPM
naive B-cell: 8.3 nTPM
neutrophil: 4.6 nTPM
plasmacytoid DC: 4.1 nTPM
memory CD4 T-cell: 2.2 nTPM
memory CD8 T-cell: 2 nTPM

Brain region

choroid plexus: 23 nTPM
medulla oblongata: 11 nTPM
midbrain: 11 nTPM
spinal cord: 8.3 nTPM
pons: 7.5 nTPM
amygdala: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Centrosome-associated contractile fiber protein

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC191 as an antibody target. Whether an autoantibody or antibody against CCDC191 could matter depends on whether native CCDC191 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC191 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC191 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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