Seroatlas · Human Serome Atlas

CCDC190

Coiled-coil domain-containing protein 190

Also known as: C1orf110, CC190_HUMAN, MGC48998

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86UF4
Gene: CCDC190
Ensembl: ENSG00000185860
Chromosome: 1
Canonical length: 302 aa
Protein class: Predicted intracellular proteins
Subcellular location: Actin filaments,Cytosol

OverviewNCBI Gene

No narrative summary is available for CCDC190 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

302 residues, UniProt reviewed canonical sequence.

>Q86UF4|CCDC190
     1  MERHMVRGQL YKHFDLERKN AKQAEARLDQ RLQRLKVICL YHVKLLTWEQ RQLQKELQRL
    61  QQAETMKKKF SSYLGNGFQK RPEDVLVFSP QGRQKHRAPQ AKKMRALATR MAQDTCKSKS
   121  QVPPSHDAGL KDPMKSKKQP LSQNNRTACF IKEQPQAQEK DSVNPSKDVD PSKGISVPCQ
   181  NQEVSTNTIE QGPSSSPASD SGMACADETR SKDVALKPDG NTGKQIPPKH MECAGSFEGE
   241  FTKPTFLELL SKARNAHYLR HRVPPESERL LSIGEIFGHG ESSSSRAGKE CENRVPSKFL
   301  PL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC190 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 2.6 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 2.6 nTPM
esophagus: 2.5 nTPM
lung: 1.5 nTPM
basal ganglia: 0.5 nTPM
choroid plexus: 0.5 nTPM
hippocampal formation: 0.4 nTPM

Single-cell type

respiratory ciliated cells: 381 nCPM
ependymal cells: 38 nCPM
respiratory deuterosomal cells: 32 nCPM
astrocytes: 26 nCPM
conjunctival goblet cells: 13 nCPM
esophageal suprabasal cells: 10 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 3.3 nTPM
thalamus: 3.2 nTPM
white matter: 3.2 nTPM
midbrain: 3.1 nTPM
medulla oblongata: 2.4 nTPM
hippocampal formation: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 190
Coiled-coil domain-containing protein 190

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC190 as an antibody target. Whether an autoantibody or antibody against CCDC190 could matter depends on whether native CCDC190 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC190 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC190 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...