Seroatlas · Human Serome Atlas

CCDC188

Coiled-coil domain-containing protein 188

Also known as: CC188_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
H7C350
Gene
CCDC188
Ensembl
ENSG00000234409
Chromosome
22
Canonical length
402 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm,Nuclear bodies,Flagellar centriole

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>H7C350|CCDC188
     1  MEGLKTLGPC GHPHPQCPPT PASSSHGGGL DQPCQGFVGW PCLGPISSAH SVQSQRPFPV
    61  PGAGGSGPTV EGEAPGLFLS SQEQRARDTE GPRQGDLEAG LGWGWPLHPG SNQGAPRQGG
   121  SIGSGTRPCP CPPLSREGGA LASPRVALSQ LQCGLLGSAE QSFLQLEQEN HSLKRQNQEL
   181  REQLGALLGP GQQFLPLCPE HSSCTALAWP PDPAGTQPLG NRAPLQLLRR ELCQGQEAFV
   241  QQSQNELQQI RLCFERKKMV ITEVWDNVAE MHMALNNQAT GLLNLKKDIR GVLDQMEDIQ
   301  LEILRERAQC RTRARKEKQM ASMSKGRPKL GSSKGLAGQL WLLTLRLLLG ALLVWTAAYV
   361  YVVNPTPFEG LVPPLLSRAT VWKLRALLDP FLRLKVDGFL PF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC188 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • testis: 39 nTPM
  • pituitary gland: 9.6 nTPM
  • hypothalamus: 3 nTPM
  • cerebellum: 2.5 nTPM
  • adipose tissue: 1.5 nTPM
  • spleen: 1.5 nTPM

Single-cell type

  • late spermatids: 1,494 nCPM
  • early spermatids: 420 nCPM
  • late primary spermatocytes: 32 nCPM
  • neuroendocrine cells: 6 nCPM
  • endometrial ciliated cells: 4.5 nCPM
  • gonadotrophs: 4 nCPM

Immune cell

  • plasmacytoid DC: 1.5 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • thalamus: 8.7 nTPM
  • hypothalamus: 8.2 nTPM
  • basal ganglia: 6.5 nTPM
  • hippocampal formation: 6.3 nTPM
  • cerebellum: 6.2 nTPM
  • cerebral cortex: 6.2 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC188 as an antibody target. Whether an autoantibody or antibody against CCDC188 could matter depends on whether native CCDC188 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC188 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC188 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC188. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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