Seroatlas · Human Serome Atlas

CCDC187

Coiled-coil domain-containing protein 187

Also known as: CC187_HUMAN, MGC50722

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A096LP49
Gene: CCDC187
Ensembl: ENSG00000260220
Chromosome: 9
Canonical length: 1063 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable microtubule binding activity. Predicted to be involved in microtubule anchoring. Predicted to be located in centrosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1063 residues, UniProt reviewed canonical sequence.

>A0A096LP49|CCDC187
     1  MPTLVVGTPP TCLGDTPQPC HKNSQRQGPF SHGAPGRAAD WKAVAKPRLC APAAEDDVAA
    61  LRWPGPSQQP DPPWAAPHVV GSDDLKEPGP WGKACSLPMW STGPEARDGD SSVSSGRLSC
   121  SSGGHDVCVS WKERPPQVLG PQQRPRKSDA RLEQLRDKIR AQAWQQGSCA SLGTSAPSSA
   181  SRLHKASTLM LRRKGQEAKN PPPAPECSGF SILSAAERRV EAKASHGQGR ELSRVSQHQV
   241  PVLREKPKRV KSSSCKREKT PKLPSPRRAA KDKHKDEDSE LVGVYAWRKG QALVRSLLGP
   301  PPVLRRHHSK DPSRDPALTV DLGDSEKVIA AKCSPVCAQL PDATSAYSDQ QVSGNTPSLA
   361  SFDQPATIQT AMAILQDLRQ QIQAGLELAQ ARKGGQELGP SKRRLQDVAG RGCCRDPNAQ
   421  SSFSKSPWAM TERKHSSLER ARSVHTWEPW SSSTARESCP QRAWGAQGQD RSFQRPESPH
   481  ERLGHFSQRP WSALAGQACS PQRAWGAQRQ GPSSQRPGSP PEKRSPFPQQ PWSAVATQPC
   541  PRRAWTACET WEDPGPRLRN PLERPSPPAQ RPWSSSGVQR AGPQGKGRGI GSPVSAAKHA
   601  LPRPTGSFPQ NPLGKEKDTL RPCPRSRGLL GPSHSSESLR EFMRQKAQAR RRQALEEKAS
   661  ALRTRELRSR RLQEVYRQQR EAVLGRAVPV VSRTTPGIVT FVPSSAQSGG LEASGSLESP
   721  VLEWSKVTSG MVLGGQEAPG SFCLCLNRAW NHAETLDPPG MGGPQDGRDA PVLLSASPSL
   781  GSLELQDLTT RYLPRGMCIY LDPKEAEHLG TSSSLHLRHK QAQLQALETT AKVLKQRVDS
   841  LTAKLQGAEA LDTVRDPAVG LLRSCPHSLP AAPTLATPTL ATPACPGALG PNWGRGAPGE
   901  WVSMQPQPLL PPTYFLDGET LSWGPSWEQQ QSVSPRAHCE SKPRGFPEEG HVDVKPDKRL
   961  QRGVAPFQAL SPSAGSSYAG PATLHPIWGS LGLEETPSVG GADSVAPCTP RSCGKGDPAD
  1021  RPWAGWSGGR GIHREHLPLP STRAWPYGVE KSFSTWRAST PRY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC187 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

testis: 28 nTPM
fallopian tube: 7.1 nTPM
pituitary gland: 6.7 nTPM
thyroid gland: 4.6 nTPM
epididymis: 2.6 nTPM
lung: 2 nTPM

Single-cell type

late spermatids: 913 nCPM
early spermatids: 161 nCPM
respiratory ciliated cells: 130 nCPM
endometrial ciliated cells: 120 nCPM
fallopian tube ciliated cells: 90 nCPM
epididymal principal cells: 63 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 1.6 nTPM
choroid plexus: 0.9 nTPM
midbrain: 0.7 nTPM
cerebellum: 0.5 nTPM
medulla oblongata: 0.4 nTPM
amygdala: 0.3 nTPM

OntologyGO

Protein domainsUniProt · Pfam · InterPro

Centrosome-associated protein 350/Coiled-coil domain-containing protein 187

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC187 as an antibody target. Whether an autoantibody or antibody against CCDC187 could matter depends on whether native CCDC187 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC187 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC187 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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